Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, July 5, 2018

Oxidative Stress and Nitric Oxide in Cerebral Ischemic Reperfusion Injury

With NO protocol written up on this and no delivery to stroke hospitals you may as well not even do any research. We need solutions not just lazy descriptions of problems. 

Oxidative Stress and Nitric Oxide in Cerebral Ischemic Reperfusion Injury




  • Zhong Liu
  • Zhongsong ShiEmail author

    1. 1.Department of NeurosurgerySun Yat-sen Memorial Hospital of Sun Yat-sen UniversityGuangzhouChina
    Chapter
    First Online:
    Part of the Springer Series in Translational Stroke Research book series (SSTSR)


    Abstract

    Cerebral ischemic reperfusion injury is a heterogeneous phenomenon with a multi-factorial etiology, and characterized as a cascade of neurochemical processes evolving in time and space after restriction or sudden interruption of cerebral blood flow. It has been suggested that oxidative stress and nitrosative stress are important mechanisms in cerebral ischemic reperfusion. The concept of oxidative and nitrosative stress stem from the generation of the reactive oxygen species (ROS) involving the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) family and the reactive nitrogen species (RNS) including nitric oxide (NO) and peroxynitrite (ONOO−) at rates which exceed the capacity of natural antioxidant and anti-nitrification defense mechanisms to detoxify these toxic products. This review is focusing on the role of oxidative and nitrosavtive stress in cerebral ischemic reperfusion injury by discussing the concepts, the mechanisms, and the pharmacological approaches of ROS and RNS modulation for preventing cerebral ischemic reperfusion injury.

    Keywords

    Cerebral ischemic reperfusion injury Oxidative stress 
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