Now more reasons for coffee. I bet your stroke hospital even with this information will not set up a 24 hour coffee station. Years and years of incompetency already. Notice the 8 cups a day, I'm close to that level now that I got a new coffee maker that does 10 cups at a time. You need an accessible coffee station for that.
Association of coffee drinking with mortality by genetic variation in caffeine metabolism: Findings From the UK Biobank
- The UK Biobank is a population-based study that welcomed approximately 9.2 million people from across the United Kingdom to take an interest.
- Researchers utilized baseline demographic, lifestyle, and genetic data form the UK Biobank cohort, with follow-up starting in 2006 and ending in 2016, to assess hazard ratios (HRs) for coffee intake and mortality, utilizing multivariable-adjusted Cox proportional hazards models.
- Potential effect modification was investigated by caffeine metabolism, characterized by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.
- Of the 502,641 members who consented with baseline data, those who were not pregnant and had complete data on coffee intake and smoking status (n = 498,134) were included.
- Total, ground, instant, and decaffeinated coffee intake were the analyzed exposures.
- All-cause and cause-specific mortality were the main outcomes and measures.
- The study results showed that the mean age of the participants was 57 years (range, 38-73 years); 271 019 (54%) were female, and 387,494 (78%) were coffee drinkers.
- It was observed that 14,225 deaths occurred over 10 years of follow-up.
- Findings revealed that coffee drinking was inversely associated with all-cause mortality.
- HRs for drinking less than 1, 1, 2 to 3, 4 to 5, 6 to 7, and 8 or more cups per day were 0.94 (95% CI, 0.88-1.01), 0.92 (95% CI, 0.87-0.97), 0.88 (95% CI, 0.84-0.93), 0.88 (95% CI, 0.83-0.93), 0.84 (95% CI, 0.77-0.92), and 0.86 (95% CI, 0.77-0.95), respectively using non–coffee drinkers as the reference group.
- Data reported that similar associations were noted for instant, ground, and decaffeinated coffee, across common causes of death, and regardless of genetic caffeine metabolism score.
- According to the findings obtained, the HRs for 6 or more cups per day ranged from 0.70 (95% CI, 0.53-0.94) to 0.92 (95% CI, 0.78-1.10), with no evidence of effect modification across strata of caffeine metabolism score (P=.17 for heterogeneity).