Even if you have genes that don't process caffeine fast you're ok.
Genetics determine how much coffee you can drink before it goes wrong
Now more reasons for coffee. I bet your stroke hospital even with this
information will not set up a 24 hour coffee station. Years and years of
incompetency already. Notice the 8 cups a day, I'm close to that level now that I got a new coffee maker that does 12 cups at a time. You need an accessible
coffee station for that.
Association of coffee drinking with mortality by genetic variation in caffeine metabolism: Findings From the UK Biobank
JAMA Internal Medicine — Loftfield E, et al. | July 09, 2018
In this large prospective cohort study, the researchers assessed
associations of coffee drinking with mortality by genetic caffeine
metabolism score. Data reported that coffee drinking was inversely
linked with mortality, including among those drinking 8 or more cups per
day and those with genetic polymorphisms showing slower or faster
caffeine metabolism. The study findings suggested that coffee drinking
can be part of a healthy diet and offers reassurance to coffee drinkers.
Methods
- The UK Biobank is a population-based study that welcomed approximately 9.2 million people from across the United Kingdom to take an interest.
- Researchers utilized baseline demographic, lifestyle, and genetic data form the UK Biobank cohort, with follow-up starting in 2006 and ending in 2016, to assess hazard ratios (HRs) for coffee intake and mortality, utilizing multivariable-adjusted Cox proportional hazards models.
- Potential effect modification was investigated by caffeine metabolism, characterized by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.
- Of the 502,641 members who consented with baseline data, those who were not pregnant and had complete data on coffee intake and smoking status (n = 498,134) were included.
- Total, ground, instant, and decaffeinated coffee intake were the analyzed exposures.
- All-cause and cause-specific mortality were the main outcomes and measures.
Results
- The study results showed that the mean age of the participants was 57 years (range, 38-73 years); 271 019 (54%) were female, and 387,494 (78%) were coffee drinkers.
- It was observed that 14,225 deaths occurred over 10 years of follow-up.
- Findings revealed that coffee drinking was inversely associated with all-cause mortality.
- HRs for drinking less than 1, 1, 2 to 3, 4 to 5, 6 to 7, and 8 or more cups per day were 0.94 (95% CI, 0.88-1.01), 0.92 (95% CI, 0.87-0.97), 0.88 (95% CI, 0.84-0.93), 0.88 (95% CI, 0.83-0.93), 0.84 (95% CI, 0.77-0.92), and 0.86 (95% CI, 0.77-0.95), respectively using non–coffee drinkers as the reference group.
- Data reported that similar associations were noted for instant, ground, and decaffeinated coffee, across common causes of death, and regardless of genetic caffeine metabolism score.
- According to the findings obtained, the HRs for 6 or more cups per day ranged from 0.70 (95% CI, 0.53-0.94) to 0.92 (95% CI, 0.78-1.10), with no evidence of effect modification across strata of caffeine metabolism score (P=.17 for heterogeneity).
Read the full article on JAMA Internal Medicine
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