Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Monday, July 9, 2018

Association of coffee drinking with mortality by genetic variation in caffeine metabolism: Findings From the UK Biobank

Even if you have genes that don't process caffeine fast you're ok.

Genetics determine how much coffee you can drink before it goes wrong


Now more reasons for coffee. I bet your stroke hospital even with this information will not set up a 24 hour coffee station.  Years and years of incompetency already. Notice the 8 cups a day, I'm close to that level now that I got a new coffee maker that does 10 cups at a time. You need an accessible coffee station for that. 

Association of coffee drinking with mortality by genetic variation in caffeine metabolism: Findings From the UK Biobank

JAMA Internal MedicineLoftfield E, et al. | July 09, 2018
In this large prospective cohort study, the researchers assessed associations of coffee drinking with mortality by genetic caffeine metabolism score. Data reported that coffee drinking was inversely linked with mortality, including among those drinking 8 or more cups per day and those with genetic polymorphisms showing slower or faster caffeine metabolism. The study findings suggested that coffee drinking can be part of a healthy diet and offers reassurance to coffee drinkers.

Methods

  • The UK Biobank is a population-based study that welcomed approximately 9.2 million people from across the United Kingdom to take an interest.
  • Researchers utilized baseline demographic, lifestyle, and genetic data form the UK Biobank cohort, with follow-up starting in 2006 and ending in 2016, to assess hazard ratios (HRs) for coffee intake and mortality, utilizing multivariable-adjusted Cox proportional hazards models.
  • Potential effect modification was investigated by caffeine metabolism, characterized by a genetic score of previously identified polymorphisms in AHR, CYP1A2, CYP2A6, and POR that have an effect on caffeine metabolism.
  • Of the 502,641 members who consented with baseline data, those who were not pregnant and had complete data on coffee intake and smoking status (n = 498,134) were included.
  • Total, ground, instant, and decaffeinated coffee intake were the analyzed exposures.
  • All-cause and cause-specific mortality were the main outcomes and measures.

Results

  • The study results showed that the mean age of the participants was 57 years (range, 38-73 years); 271 019 (54%) were female, and 387,494 (78%) were coffee drinkers.
  • It was observed that 14,225 deaths occurred over 10 years of follow-up.
  • Findings revealed that coffee drinking was inversely associated with all-cause mortality.
  • HRs for drinking less than 1, 1, 2 to 3, 4 to 5, 6 to 7, and 8 or more cups per day were 0.94 (95% CI, 0.88-1.01), 0.92 (95% CI, 0.87-0.97), 0.88 (95% CI, 0.84-0.93), 0.88 (95% CI, 0.83-0.93), 0.84 (95% CI, 0.77-0.92), and 0.86 (95% CI, 0.77-0.95), respectively using non–coffee drinkers as the reference group.
  • Data reported that similar associations were noted for instant, ground, and decaffeinated coffee, across common causes of death, and regardless of genetic caffeine metabolism score.
  • According to the findings obtained, the HRs for 6 or more cups per day ranged from 0.70 (95% CI, 0.53-0.94) to 0.92 (95% CI, 0.78-1.10), with no evidence of effect modification across strata of caffeine metabolism score (P=.17 for heterogeneity).
Read the full article on JAMA Internal Medicine

No comments:

Post a Comment