Deans' stroke musings: Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, July 1, 2020

Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease

Ask your doctor what they are using levodopa for in your recovery. No knowledge is grounds for firing.

Early Promise For Stroke Patients Given - levodopa back to Sept. 2001.

levodopa (11 posts to May 2012)

Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease

Show all authors

Diego Orcioli-Silva, PhD

, Rodrigo Vitório, PhD

, Priscila Nóbrega-Sousa, MSc

, ...

First Published May 25, 2020 Research Article Find in PubMed

Abstract

Background.
Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective.
To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD.
Methods.
A total of 20 individuals with PD (69.8 ± 5.9 years) and 30 healthy older people (68.0 ± 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO₂) from the left and right PFC were measured.
Results.
People with PD in the off state did not present changes in HbO₂ level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO₂ levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO₂ levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state.
Conclusions.
PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment.

Keywords gait, fNIRS, dopamine, cognition, Parkinson disease