Deans' stroke musings: Antihistamine Sparks Hope for Myelin Repair in Multiple Sclerosis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, June 13, 2023

Antihistamine Sparks Hope for Myelin Repair in Multiple Sclerosis

So the implication is that myelin is damaged in your stroke so your doctor needs protocols to repair that damage. Will this do it?

Didn't your doctor already have this done 6 years ago?

Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury December 2017

Individuals with higher levels of physical activity after stroke show comparable patterns of myelin to healthy older adults

The latest here:

Antihistamine Sparks Hope for Myelin Repair in Multiple Sclerosis

Summary: A new study paves the way for potential treatments for Multiple Sclerosis (MS) by identifying the OTC antihistamine, clemastine, as an effective drug for brain repair. Utilizing a newly-developed MRI scan technique, scientists were able to observe and measure the impact of clemastine on brain myelin levels.

The study offers the first documented example of brain repair for a chronic neurological condition through MRI. These results are expected to set a standard for future research into myelin-rebuilding therapies.

Key Facts:

Clemastine, an over-the-counter antihistamine, has been identified as a potential therapy for MS, with observed increases in myelin water fraction indicating myelin repair.
A unique MRI technique was used to measure changes in myelin levels before and after the drug was administered, setting a new standard for tracking myelin recovery.
Beyond its potential impact on MS, clemastine is also being considered for use in treating brain injury in premature infants, who often experience myelin damage.

Source: UCSF

A decade after UC San Francisco scientists identified an over-the-counter antihistamine as a treatment for multiple sclerosis, researchers have developed an approach to measure the drug’s effectiveness in repairing the brain, making it possible to also assess future therapies for the devastating disorder.

The researchers, led by physician-scientist Ari Green, MD, who together with neuroscientist Jonah Chan, Ph.D., first identified clemastine as a potential MS therapy, used MRI scans to study the drug’s impact on the brain of 50 participants in a clinical study.

In MS, patients lose myelin, the protective insulation around nerve fibers. This myelin loss triggers delays in nerve signals, leading to weakness and spasticity, vision loss, cognitive slowing and other symptoms.