Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 1, 2023

Prevalence of Antiphospholipid Antibodies May Signal Future Risk of MI, Stroke

With your risk of dementia post stroke it is imperative your doctor performs this test on you and have protocols in place to prevent your likely chances of dementia.

Your risk of dementia, has your doctor told you of this?  Your doctor is responsible for preventing this!

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018 

The latest here:

Prevalence of Antiphospholipid Antibodies May Signal Future Risk of MI, Stroke

Seemingly healthy people whose blood contained antibodies associated with antiphospholipid syndrome (APS) were significantly more likely to experience a cardiovascular event, according to a study published in JAMA Network Open.

“In this population-based cohort study including 2,427 participants, the prevalence


of any antiphospholipid antibodies tested by solid-phase assays at a single time point was 14.5%, with approximately one-third of those detected at a moderate or high titre,” reported James de Lemos, MD, University of Texas Southwestern, Dallas, Texas, and colleagues. “The IgA [immunoglobulin A] isotypes of anticardiolipin and anti-beta-2 glycoprotein I were associated with future atherosclerotic cardiovascular disease events.”

The research team tested blood that had been collected from study participants between 2007 and 2009 and looked for the presence and amounts of 8 different antiphospholipid antibodies. They analysed these data along with questionnaire responses gathered during a follow-up period that averaged 8 years to see which participants experienced a cardiovascular event, including myocardial infarction (MI), stroke, coronary bypass surgery, or death from cardiovascular disease.

The researchers detected antiphospholipid antibodies in about 14.5% of the 2,427 study participants. About a third of those had antibody levels that were considered moderate or high. Over the follow-up period, 125 individuals experienced cardiovascular events.

After adjusting for risk factors such as age, sex, race, body mass index, smoking history, cholesterol levels, and diabetes, the researchers found that the presence of 2 particular antiphospholipid antibodies -- aCL IgA and ab2GPI IgA -- was associated with a future cardiovascular event. In participants with relatively higher levels of these 2 antibodies, this connection was even stronger.

Dr. de Lemos noted that because antibody levels can be transient and blood samples were done on a single visit, more studies are needed to better understand whether antiphospholipid antibodies remain elevated in people without diagnosed APS and how this might relate to heart disease.

Ravi Sarode, MD, University of Texas Southwestern, said that if further research supports the study’s initial findings, labs would be able to test patients for antiphospholipid antibodies.

“These antibodies are easy to test; we test them all the time in our lab for certain patients,” said Dr. Sarode. “It is very important to note that very few labs test for these specific antibodies. However, we would need more information to use them in the right clinical setting for patients who may be at higher risk of MI or stroke.”

Reference: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2803031

SOURCE: University of Texas Southwestern Medical Center

No comments:

Post a Comment