Deans' stroke musings: Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, October 1, 2025

Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke

Another useless piece of describing a problem with NO solution provided! I'd fire everyone involved in this crapola!

Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke

Spencer P. Loewen, PhD Nishita Singh, MD Ibrahim Alhabli,MD^3,4,5 Author Affiliations Article Information Cite Permissions Comments JAMA Netw Open

Published Online: September 30, 2025 doi:10.1001/jamanetworkopen.2025.34941 Supplemental Content

Question

Are neuroimaging markers of brain frailty associated with functional outcomes in patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis?In this cohort study of 1568 patients with AIS, the severity of white matter changes, cortical atrophy, and a total brain frailty score capturing the aggregate burden were each associated with worse functional outcomes at 90 days.

Meaning These findings suggest that brain frailty assessment on baseline neuroimaging using clinical rating scales provides prognostic information for clinicians and patients regarding functional outcomes after reperfusion therapies for AIS, including intravenous thrombolysis with alteplase or tenecteplase.