Our researchers should be able to follow this research to figure out how to guide axons around dead areas to reconnect up the various parts of the brain. It might be challenging to do but no more challenging than recovering from a stroke. And they have full use of their brains. No excuses allowed.
http://psychcentral.com/news/2013/06/08/how-your-brain-circuits-become-miswired/55790.html
How do the faulty brain circuits involved in mental disorders such as autism
or retardation develop? Researchers at Weill Cornell Medical College
have helped light the way to an answer with the discovery of a mechanism
that guides the wiring of neural circuits in a developing brain.
The researchers discovered that faulty wiring occurs when RNA
molecules embedded in a growing axon are not degraded after they give
instructions that help steer the nerve cell.
For example, the signal that tells the axon to turn — which should
disappear after the turn is made — remains active, interfering with new
signals meant to guide the axon in other directions.
“Understanding the basis of brain miswiring can help scientists come
up with new therapies and strategies to correct the problem,” said the
study’s senior author, Samie Jaffrey, M.D., Ph.D.
“The brain is quite plastic and changeable in the very young, and if
we know why circuits are miswired, it may be possible to correct those
pathways, allowing the brain to build new, functional wiring.”
Disorders associated with faulty neuronal circuits include epilepsy, autism, schizophrenia, mental retardation and spasticity and movement disorders, he noted.
During brain development, neurons have to connect to each other,
which they do by extending their long axons to touch one another, the
researchers explain. Ultimately, the neurons form a circuit between the
brain and the target tissue through which chemical and electrical
signals are relayed.
In the new study, researchers looked at neurons that travel up the spinal cord into the brain.
“It is very critical that axons are precisely positioned in the
spinal cord,” Jaffrey said. “If they are improperly positioned, they
will form the wrong connections, which can lead to signals being sent to
the wrong target cells in the brain.”
The way that an axon guides and finds its proper target is through “growth cones” located at the tips of axons, he said.
“These growth cones have the ability to sense the environment,
determine where the targets are and navigate toward them,” he continued.
“The question has always been — how do they know how to do this? Where
do the instructions come from that tell them how to find their proper
target?”
The researchers found that RNA molecules embedded in the growth cone
are responsible for instructing the axon to move left or right, up or
down. These RNAs produce antenna-like proteins that steer the axon like a
self-guided missile.
“As a circuit is being built, RNAs in the neuron’s growth cones are
mostly silent,” he explained. “We found that specific RNAs are only read
at precise stages in order to produce the right protein needed to steer
the axon at the right time. After the protein is produced, we saw that
the RNA instruction is degraded and disappears.”
“If these RNAs do not disappear when they should, the axon does not
position itself properly — it may go right instead of left — and the
wiring will be incorrect and the circuit may be faulty,” he continued.
The researchers didn’t anticipate that the control of brain wiring is
located in these RNA molecules that are “constantly being dynamically
turned over,” Jaffrey said.
“This tells us that regulating these RNA degradation pathways could
have a tremendous impact on brain development,” he said. “Now we know
where to look to tease apart this process when it goes awry, and to
think about how we can repair it.”
The study was published in the journal Cell.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,116 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
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