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The latest here:
Licorice Extract May Help Prevent and Treat Parkinson’s
Source: DGIST.
DGIST’s research team led by Dr. Yun-Il Lee in Well Aging Research Center has identified a new mechanism of inhibition of dopaminergic neuronal apoptosis and suggested the possibility of preventing and treating Parkinson’s disease.
Parkinson’s disease (PD) is a typical degenerative brain disease caused by the death of dopaminergic neurons in the middle cerebral blood. It is a disease with a higher incidence in the population aged 60 or older, exhibiting symptoms such as tremor, stiffness, slow motion and postural instability.
In particular, as the majority of Parkinson’s patients suffer from the progressive neurodegenerative disease, many researchers newly started to focus on cell death, a loss of dopamine-producing neurons, to treat PD. With regard to the cell death process, in vivo cell stress and damages activate PARP-1 (Poly ADP-ribose polymerase-1) and induce excessive accumulation of PAR (Poly ADP-ribose) and those activities activate AIF (Apoptosis-Inducing Factor), a factor that induces cell death, and destroy DNA. This new mechanism of cell death (Parthanatos) has recently been known as the cause of degenerative brain diseases such as Parkinson’s disease, stroke, heart attack, diabetes, etc. and the mechanism has been extensively studied as previous research to treat these diseases.
Currently, medications are being used to alleviate symptoms of Parkinson’s disease. However, there are no government-approved drugs that can inhibit dopaminergic neuronal cell death. Then, the research teams have found the possibility in licorice, the herb medicine.
Dr. Yun-Il Lee carried out joint research with Professor Joo-Ho Shin and Professor Yunjong Lee from Sungkyunkwan University School of Medicine to study candidate compounds for the treatment of Parkinson’s disease. For example, the researchers have identified the mechanism that cortisol, a stress hormone, promotes dopaminergic neuronal activity by inducing parkin protein expression that inhibits dopamine neuronal cell death.
In this study, the research teams found the candidate drugs that induce the expression of RNF146 protein involved in the inhibition of neuronal cell death through high-speed mass screening method using the natural materials library of the Natural Medicine Bank of Korea Foundation.
Mechanism
of inhibition of dopamine neuronal cell death by Liquiritigenin : When
mitochondrial function is impaired by active oxygen, MPP +, rotenone,
6-OHDA, and α-synuclein fibril, the activation of PARP1 causes DNA
damage. In addition, the accumulation of the substrate AIMP2 of the
parkin protein induces hyperactivity of PARP1 and results in cell death
of dopaminergic neurons. Liquiritigenin inhibits dopamine neuronal cell
death in Parkinson’s disease as it binds to the estrogen receptor beta
and is transported to the nucleus, stimulates transcription of RNF146
and controls the activation of PARP1. NeuroscienceNews.com image is
credited to Daegu Gyeongbuk Institute of Science and Technology (DGIST).
In addition, the research teams have been working on identifying the mechanism which induces liquiritigenin’s RNF146 protein expression and demonstrated that it regulates transcription through binding and activity with estrogen receptors in cell and animal models. Consequently, it has been scientifically proved that liquiritigenin, a licorice extract, can be used as a treatment for degenerative Parkinson’s disease.
Dr. Yun-Il Lee stated “Neuronal death is involved in a variety of signaling systems in vivo. Therefore, it is essential to identify a new mechanism that is able to control the system comprehensively and we have found additional possibilities in licorice extract.” He added “I would like to contribute to the treatment of degenerative brain diseases such as Parkinson’s disease by conducting advanced researches, comprehensive research and clinical studies.”
About this neuroscience research article
Source: Dajung Kim – DGISTPublisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Daegu Gyeongbuk Institute of Science and Technology (DGIST).
Original Research: Full open access research for “Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson’s disease models” by Hyojung Kim, Sangwoo Ham, Joon Yeop Lee, Areum Jo, Gum Hwa Lee, Yun-Song Lee, MyoungLae Cho, Heung-Mook Shin, Donghoon Kim, Olga Pletnikova, Juan C. Troncoso, Joo-Ho Shin, Yun-Il Lee and Yunjong Lee in Oncotarget. Published online November 2017 doi:10.18632/oncotarget.21828
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