Only in mice so nothing will ever occur since there will be NO followup. Our stroke leaders are that fucking useless.
Growth Hormone Improves Cognitive Function After Experimental Stroke
Visual Overview
Abstract
Background and Purpose—Cognitive
impairment is a common outcome for stroke survivors. Growth hormone
(GH) could represent a potential therapeutic option as this peptide
hormone has been shown to improve cognition in various clinical
conditions. In this study, we evaluated the effects of peripheral
administration of GH at 48 hours poststroke for 28 days on cognitive
function and the underlying mechanisms.
Methods—Experimental
stroke was induced by photothrombotic occlusion in young adult mice. We
assessed the associative memory cognitive domain using mouse
touchscreen platform for paired-associate learning task. We also
evaluated neural tissue loss, neurotrophic factors, and markers of
neuroplasticity and cerebrovascular remodeling using biochemical and
histology analyses.
Results—Our
results show that GH-treated stroked mice made a significant
improvement on the paired-associate learning task relative to
non–GH-treated mice at the end of the study. Furthermore, we observed
reduction of neural tissue loss in GH-treated stroked mice. We
identified that GH treatment resulted in significantly higher levels of
neurotrophic factors (IGF-1 [insulin-like growth factor-1] and VEGF
[vascular endothelial growth factor]) in both the circulatory and
peri-infarct regions. GH treatment in stroked mice not only promoted
protein levels and density of presynaptic marker (SYN-1 [synapsin-1])
and marker of myelination (MBP [myelin basic protein]) but also
increased the density and area coverage of 2 major vasculature markers
(CD31 and collagen-IV), within the peri-infarct region.
Conclusions—These
findings provide compelling preclinical evidence for the usage of GH as
a potential therapeutic tool in the recovery phase of patients after
stroke.
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