Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, January 13, 2019

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): A pragmatic, double-blind, randomised, controlled trial

 So it seems antidepression meds do not increase motor recovery. Ask your doctor to analyze all sets of research to determine which way to go. Well, fuck, the Rankin scale has nothing objective in it at all except for 6 - death. Using the Rankin scale is stupid, it has very limited discriminatory power and is not objective. 

Common antidepressant can help stroke patients improve movement and coordination Sept. 2015 

 

Antidepressants may help people recover from stroke even if they are not depressed Jan. 2013

 

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): A pragmatic, double-blind, randomised, controlled trial


The Lancet | January 10, 2019
In this FOCUS trial collaboration, researchers assessed the effects fluoxetine on functional outcomes after stroke. Overall, they did not observe any benefits of providing fluoxetine 20 mg daily for 6 months after acute stroke in terms of functional outcomes. The treatment reduced the occurrence of depression but increased the frequency of bone fractures. Thus, the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function was not supported.

Methods

  • This multicenter, parallel group, double-blind, randomized, placebo-controlled trial was conducted at 103 UK hospitals.
  • Study participants included adults with a clinical stroke diagnosis who were randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits.
  • Participants received either fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimization algorithm.
  • Functional status, measured with the modified Rankin Scale (mRS), at 6 months was assessed as the primary outcome.
  • Treatment allocation was not revealed to patients, care givers, healthcare staff, or the trial team.
  • Assessment of functional status was done at 6 months and 12 months after randomization.
  • As per the treatment allocation, analysis of the patients was done.

Results

  • A total of 3,127 patients were recruited between September 10, 2012, and March 31, 2017.
  • Researchers allocated 1,564 patients to receive fluoxetine and 1,563 to receive placebo.
  • In each treatment group, 1,553 (99.3%) patients had mRS data available at 6 months.
  • The fluoxetine and placebo groups had similar distribution across mRS categories at 6 months.
  • Patients who received fluoxetine displayed less tendency for developing new depression by 6 months vs those who received placebo; however, these patients had more bone fractures.
  • No significant differences in any other event at 6 or 12 months was noted.
Read the full article on The Lancet

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