But you don't even discuss the whole point of tPA, 100% recovery. Anything less is the tyranny of low expectations and that needs to be eliminated. And since you don't know how fast it needs to be applied you don't even know the goal. Damn it all, start solving stroke, not just beating around the edges.
Association between thrombolytic door-to-needle time and 1-year mortality and readmission in patients with acute ischemic stroke
Man S, Xian Y, Holmes DN, et al
JAMA|June 3, 2020
This
retrospective cohort study was undertaken to determine if shorter
door-to-needle times with intravenous tissue plasminogen activator (tPA)
for acute ischemic stroke are correlated with improved long-term
outcomes. The authors included Medicare beneficiaries aged 65 years or
older who were treated for acute ischemic stroke with intravenous tPA
within 4.5 hours from the time they were last considered to be well at
Get With The Guidelines–Stroke participating hospitals between January
1, 2006, and December 31, 2016, with 1-year follow-up through December
31, 2017. Of the 61,426 patients treated within 4.5 hours with tPA, the
median age was 80 years and 43.5% were male. Shorter door-to-needle
times were related to lower all-cause mortality and lower all-cause
readmission at 1 year in patients aged 65 years or older with acute
ischemic stroke who were treated with tissue plasminogen activator.
Such results support efforts to shorten thrombolytic therapy time.
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