Deans' stroke musings: AF without other CV comorbidities confers no elevated risk for stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, June 11, 2020

AF without other CV comorbidities confers no elevated risk for stroke

For discussion with your doctor.

AF without other CV comorbidities confers no elevated risk for stroke

Atrial fibrillation alone with no other CV comorbidities conferred no greater risk for stoke compared with patients with neither AF nor CV comorbidities.
However, patients without AF but with CV comorbidities experienced an elevated risk for both stroke and cardioembolic stroke, according to findings from the REGARDS study published in the Journal of the American Heart Association.

doctor talking to patient — *Source: Adobe Stock.*

Researchers classified 28,253 participants (mean age, 65 years; 55% women) into one of four groups based on the presence or absence of AF and the presence or absence of CV comorbidities.
They observed that participants with AF alone had no elevated risk for stroke compared with patients with neither AF nor CV comorbidities (HR = 1.23; 95% CI, 0.62-2.18).
“In this analysis of the REGARDS study cohort, we found no evidence of an increased risk of stroke among participants with AF without cardiovascular comorbidities, compared with the reference group of those with neither AF nor cardiovascular comorbidities,” Matthew J. Singleton, MD, MBE, MSc, MHS, of the section of cardiology at the Wake Forest School of Medicine, Winston-Salem, North Carolina, and colleagues wrote. “This finding was consistent in subgroup analyses. However, there was evidence of effect modification between age (< 64 vs. 64 years) and group. For those with cardiovascular comorbidities without AF, we found an increased risk of cardioembolic stroke, even in the absence of AF.”
In other findings, participants without AF but with CV comorbidities experienced an elevated risk for both stroke (HR = 1.77; 95% CI, 1.48-2.18) and cardioembolic stroke (HR = 2.34; 95% CI, 1.48-3.9) compared with those without AF or CV comorbidities.
“We feel that our study adds substantively to the existing literature owing to the size of the subcohort of participants with AF without cardiovascular comorbidities,” the researchers wrote. “In addition, our study is the first analysis of a large cohort of patients with AF without cardiovascular comorbidities that was able to adjust for race, education and income by utilizing a biracial nationwide prospective cohort in which there was formal adjudication of events from the medical record and long-term follow-up was available.”