Deans' stroke musings: Clathrin-Nanoparticles Efficiently Deliver BDNF to the Hippocampus, Reverse Depression and Neuroinflammation and Increase Neurogenesis, Dendritic Length and Spine Density in HIV/neuroAIDS Mouse Model

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, April 12, 2023

Clathrin-Nanoparticles Efficiently Deliver BDNF to the Hippocampus, Reverse Depression and Neuroinflammation and Increase Neurogenesis, Dendritic Length and Spine Density in HIV/neuroAIDS Mouse Model

This sounds incredibly important for our recovery. What is your doctor and hospital doing to get human testing going? NOTHING? Then you don't have a functioning stroke doctor or hospital!

BDNF (164 posts to April 2011)

Clathrin-Nanoparticles Efficiently Deliver BDNF to the Hippocampus, Reverse Depression and Neuroinflammation and Increase Neurogenesis, Dendritic Length and Spine Density in HIV/neuroAIDS Mouse Model

DOI:https://doi.org/10.1016/j.biopsych.2023.02.199

BDNF reverses depression and promotes neuroregeneration but cannot easily cross a blood-brain barrier (BBB). We delivered up to 400-fold higher CNS BDNF concentrations with Clathrin-nanoparticles (BC-NPs) than other delivery methods (Vitaliano, 2022). Our goal was to decrease neurotoxic/neuroinflammatory effects of HIV/transactivator of transcription (Tat) protein and reverse depression in Tat+ mice.

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