Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, May 21, 2024

A Review on the Mechanisms of Stroke-Induced Muscle Atrophy

And with your muscle atrophy post stroke you need solutions. Hopefully your doctor is competent enough to have EXACT stroke protocols for that. S/he has had over 10 years to come up with a solution. Did they?

muscle atrophy (23 posts to July 2013)

A Review on the Mechanisms of Stroke-Induced Muscle Atrophy

Written By

Nicholas Bovio, Genevieve M. Abd, Jennifer C. Ku, Leah C. Liu and Yong Li

Submitted: 07 February 2024 Reviewed: 11 April 2024 Published: 16 May 2024

DOI: 10.5772/intechopen.114989

Human Physiology - Annual Volume 2024 Authored by Kunihiro Sakuma

From the Annual Volume

Human Physiology - Annual Volume 2024 [Working Title]

Prof. Kunihiro Sakuma and Dr. Kotomi Sakai

A Review on the Mechanisms of Stroke-Induced Muscle Atrophy | IntechOpen

Abstract

This comprehensive review elucidates the intricate, multifactorial pathophysiology underpinning post-stroke skeletal muscle atrophy, a detrimental complication impacting patient outcomes. Post-stroke complications including dysphagia, malabsorption, and inadequate protein intake precipitate a catabolic state, exacerbating muscle wasting. The dearth of essential amino acids perpetuates proteolysis over protein synthesis, highlighting the importance of nutritional interventions. Immobility-induced disuse atrophy and dysregulation of anabolic pathways, notably IGF/Akt/PI3K, favor proteolysis, disrupting muscle protein homeostasis. Proteolytic systems including the ubiquitin-proteasome pathway and autophagy play central roles. Moreover, transcriptomic alterations, insulin resistance, autonomic dysregulation, inflammation, oxidative stress, and dysregulated microRNAs contribute to reduced muscle mass post-stroke. Notably, matrix metalloproteinases’ (MMPs) implication unveils potential therapeutic avenues via MMP inhibition. Unraveling this complex pathophysiological interplay is crucial for developing multi-modal interventions to manage post-stroke muscle atrophy effectively.