Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 17, 2024

CURCUMIN MITIGATES STRESS INDUCED DEPRESSION AND HIPPOCAMPAL DAMAGE THROUGH UPREGULATION OF BDNF EXPRESSION AND ADULT NEUROGENESIS

Since you probably have major depression issues because your competent? doctor doesn't know anything about getting you 100% recovered, maybe s/he can compensate with a curcumin prescription. But your doctor won't even know about this, so you're screwed.

All this earlier research your doctor doesn't know about, why are you seeing them?

Do you prefer your  doctor  incompetence NOT KNOWING? OR NOT DOING?

Yeah in rats but competent doctors would ensure human testing gets done.

 CURCUMIN MITIGATES STRESS INDUCED DEPRESSION AND HIPPOCAMPAL DAMAGE THROUGH UPREGULATION OF BDNF EXPRESSION AND ADULT NEUROGENESIS

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Scientia Africana, Vol. 23 (No. 2), April, 2024. Pp389-402
© Faculty of Science, University of Port Harcourt, Printed in Nigeria ISSN 1118 – 1931
CURCUMIN MITIGATES STRESS INDUCED DEPRESSION AND HIPPOCAMPAL
DAMAGE THROUGH UPREGULATION OF BDNF EXPRESSION AND ADULT
NEUROGENESIS.
¹Wogu, E. U., and ¹Edibamode, E. I.
¹Anatomy Department, University of Port Harcourt, Rivers State, Nigeria.
Received: 03-04-2024
Accepted: 24-04-2024

ABSTRACT

Chronic stress, recognized as a major precipitant of depression, has been linked to various neural alterations, including cell death, neuronal atrophy, and compromised hippocampal neurogenesis and plasticity. This study aim to scrutinize curcumin's influence on glucocorticoid hormone secretion and its subsequent effects on the structural integrity and neurogenesis of the hippocampal neurons. A total of 30 adult albino Wistar rats, each weighing between 200-250 g, were utilized for the study. The rats, excluding those in the control group, underwent a 42-day regimen of modified Chronic Unpredictable Stress (CUS) to induce depressive-like states. After inducing CUS, these rats were categorized into six groups, each receiving different oral treatments for two weeks. The treatments included 30 mg/kg body weight of curcumin, 20 mg/kg body weight of fluoxetine, or a combination of both, along with a control group that received distilled water and an olive oil treated group. The rats were tested for behavioural despair using the forced swim test and their blood samples were obtained for serum corticosterone test. Afterwards, the rats were anesthetized, transcardially perfused and the hippocampus dissected and prepared for histopathological study.
The study's multi-faceted approach encompassed behavioral, biochemical, and histological
evaluations. Behavioral despair, gauged through the forced swimming test, displayed a marked
reduction in the curcumin-treated rats compared to controls (p<0.05). Additionally, curcumin
significantly lowered serum corticosterone levels, aligning them closely with the control levels.
Histomorphological analysis of the hippocampus showed that the curcumin-treated rats exhibited
substantially less neurodegeneration, as evidenced by fewer cytoplasmic vacuolations and more
intact neuronal structures. Increased cell proliferation and BDNF level were also observed in
curcumin treated rats. This study has illuminated a multifaceted approach through which curcumin mitigates hippocampal neurodegeneration, thus showing possible therapeutic potential of curcumin in ameliorating depressive symptoms.
 
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