Remyelination and axonal integrity are needed post stroke. What are your competent? doctor's EXACT PROTOCOLS TO ACCOMPLISH THAT? Oh, your doctor doesn't have any? RUN AWAY! Since you don't have a functioning stroke doctor!
BEYOND NEUROPLASTICITY - tDCS EFFECTS ON INFLAMMATION AND REMYELINATION
Letizia
Leocani
1,2,
Silvia
Marenna2, Elena Rossi1,2, Valerio
Castoldi2, Giancarlo Comi1,3. 1University Vita-Salute San Raffaele, Milan,
Italy; 2IRCCS Scientific Institute San Raffaele, Milan, Italy; 3Dep.t of
Rehabilitation Sciences, Casa di Cura Igea, Milan, Italy
Symposium title
Unveiling the Mechanismsof tDCSinNeurorehabilitation: FromProtection
to Recovery
Abstract
Introduction:
Anodal transcranial direct current stimulation (tDCS) is
known to exert neuromodulatory effects on glial cells and neurons,
increasing brain activity, promoting plasticity and remyelination. In Multiple Sclerosis, tDCS has provided promising results in relieving several
symptoms, from pain and fatigue to sensory, motor and cognitive deficits.
However, tDCS may modulate other mechanisms that can impact directly
disease activity and its clinical impact, e.g. inflammation and
remyelination.
Methods:
With the aim of exploring these effects we use pre-clinical
models of autoimmune demyelination (autoimmune encephalomyelitis
EAE) and of toxic demyelination with little inflammation (cuprizone
intoxication) we used non-invasive visual (VEP) evoked potentials to
monitor nervous conduction along the visual pathways during the course
of the two diseases and pre and post treatment.
Results:
Anodal, cathodal or sham tDCS were applied daily for 5 consecutive days after which brain and optic nerves were collected for histology.
VEPs were significantly delayed in both models prior and after sham tDCS,
while cathodal tDCS significantly prevented the development of VEPs latency delay when administered prior to the development of EAE and
anodal tDCS significantly improved VEPs delay when administered after
the development of cuprizone-related demyelination. In both models,
tDCS led to increased myelin or paranodal integrity, reduced axonal loss
and reduced expression of inflammatory microglia/macrophages..
Conclusions:
tDCS is associated with significant improvement or preservation of nervous conduction, reduced inflammation and remyelination
and axonal integrity. These findings prompt further work exploring the
possibility to use neuromodulation as a disease-modifying treatment of
Multiple Sclerosis, beyond its recognized beneficial effects on neural
plasticity.
Research Category and Technology and Methods
Basic Research: 9. Transcranial Direct Current Stimulation (tDCS)
Keywords
tDCS, Multiple Sclerosis, Inflammation, remyelination
http://dx.doi.org/10.1016/j.brs.2024.12.439
No comments:
Post a Comment