Doing it this way to deliver drugs to the brain makes so much sense that doctors will need to reject it.
http://www.dovepress.com/articles.php?article_id=11490
Abstract: Chitosan (CS)
nanoparticles of thymoquinone (TQ) were prepared by the ionic gelation
method and are characterized on the basis of surface morphology, in
vitro or ex vivo release, dynamic light scattering, and X-ray
diffractometry (XRD) studies. Dynamic laser light scattering and
transmission electron microscopy confirmed the particle diameter was
between 150 to 200 nm. The results showed that the particle size of the
formulation was significantly affected by the drug:CS ratio, whereas it
was least significantly affected by the tripolyphosphate:CS ratio. The
entrapment efficiency and loading capacity of TQ was found to be 63.3% ±
3.5% and 31.23% ± 3.14%, respectively. The drug-entrapment efficiency
and drug-loading capacity of the nanoparticles appears to be inversely
proportional to the drug:CS ratio. An XRD study proves that TQ dispersed
in the nanoparticles changes its form from crystalline to amorphous.
This was further confirmed by differential scanning calorimetry
thermography. The flat thermogram of the nanoparticle data indicated
that TQ formed a molecular dispersion within the nanoparticles.
Optimized nanoparticles were evaluated further with the help of
scintigraphy imaging, which ascertains the uptake of drug into the
brain. Based on maximum concentration, time-to-maximum concentration,
area-under-curve over 24 hours, and elimination rate constant,
intranasal TQ-loaded nanoparticles (TQ-NP1) proved more effective in
brain targeting compared to intravenous and intranasal TQ solution. The
high drug-targeting potential and efficiency demonstrates the
significant role of the mucoadhesive properties of TQ-NP1.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,972 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Friday, November 9, 2012
Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study
Labels:
nanoparticles,
nasal
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