Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, June 10, 2024

Nanocarriers-mediated nose-to-brain drug delivery: A novel approach for the management of Alzheimer’s Disease

 Our stroke leadership should be extremely grateful for this whenever we get drugs for stroke recovery that need to get to the brain. Alas, THERE IS NO STROKE LEADERSHIP! If you think there is point me to that person; oc1dean@gmail.com. I'd like to talk to them about getting stroke solved.

Nanocarriers-mediated nose-to-brain drug delivery: A novel approach for the management of Alzheimer’s Disease

https://doi.org/10.1016/j.jddst.2024.105855
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Highlights

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    Drug delivery via nose-to-brain strategy utilizes the unique architectural features of nasal cavity, which enhance the concentration of drug in the brain and can be explored for the therapeutic intervention of Alzheimer’s disease.

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    The drawbacks associated with the nose-to-brain drug delivery includes mucociliary clearance, poor permeations and ‘nasal first pass effect’, which can be bypassed using several strategies such as usage of mucoadhesive agents, permeation enhancer, and delivery of bioactives via nanocarrier systems.

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    Utilization of nanocarriers such as polymeric nanoparticles, lipidic nanocarriers, and nanoemulsion could be an effective strategy to deliver the anti-Alzheimer’s drug through intranasal drug delivery system.

Abstract

Alzheimer’s disease is a neurodegenerative disorder affecting wide range of the population worldwide and 6th primary cause of death in the USA. The available conventional treatment strategies for Alzheimer’s disease remain insufficient due to the existence of blood-brain barrier, first pass metabolism, peripheral side effects, which limits the drug concentration at the targeted site. In this perspective, the nose-to-brain delivery of therapeutic agents has emerged as an alternative strategy over the conventional (oral and parenteral) delivery systems. Nose-to-brain strategy utilizes the unique architectural and physiological characteristic of nasal cavity, and it delivers the drug directly to the brain via olfactory route, which enhance accumulation of drug in the brain. However, there are several drawbacks associated with the intranasal drug delivery including mucociliary clearance, poor permeations and ‘nasal first pass effect’. Therefore, several approaches were explored to overcome the challenges associated with the nose-to-brain delivery route such as utilization of mucoadhesive agents or permeation enhancer or both, and delivery of bioactives via nanocarrier systems. In this review, we have explored the nose-to-brain administration route for the therapeutic interventions of Alzheimer’s disease. Through this review, we have tried to capture the attention of scientists working for the treatment strategies of Alzheimer’s disease, where the compilation of nanocarriers including polymeric nanocarriers, lipid-based nanoparticles, nanoemulsion and microemulsions that could be an effective approach towards the practical applicability of nose-to-brain delivery has been made.

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