Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, July 31, 2024

Want to live a long life? Start prioritising your friends

 Yep, but that includes social connections at bars for jazz and trivia. Which is verboten by research in the Lancet. I am vastly blessed by the number of friends I have after getting divorced and moving to Michigan. Life is great.

Safest level of alcohol consumption is none, worldwide study shows

The latest here:

Want to live a long life? Start prioritising your friends

Your social network may influence your health as much as your exercise routine. David Robson, the author of a new book about our relationships, explores the evidence and reasons for this surprising link.

If you have paid attention to the latest thinking on wellbeing and longevity, you will have noticed increasing focus on the state of our relationships. People with thriving social networks, we are told, tend to be far healthier than those who feel isolated.

Our interactions with others are so strongly linked to our longevity that the World Health Organization has just founded a new Commission on Social Connection, calling it "a global health priority".

You may be a little sceptical about these claims, and the mysterious mechanisms that are supposed to tie our physical wellbeing with the strength of our relationships. But our understanding of the "biopsychosocial" model of health has been growing for decades. While investigating the science for my book The Laws of Connection, I discovered that our friendships can influence everything from our immune system's strength to our chances of dying from heart disease.

The conclusions of this research are clear: if we want to live a long and healthy life, we should start prioritising the people around us.

The roots of the science can be traced to the early 1960s. Back then, Lester Breslow at the California State Department of Public Health set out on an ambitious project to identify the habits and behaviours that led to greater longevity. To do so, he recruited nearly 7,000 participants from the surrounding Alameda County. Through comprehensive questionnaires, he built an extraordinarily detailed picture of their lifestyles, and then tracked their wellbeing over the subsequent years.

Take part

A BBC study about your friendships

We'd like to hear about your own relationships, and the ways that they might be changing in the 21st Century. To take part in our anonymous study about friendship, complete this short questionnaire we've designed with the help of psychologist Ian MacRae. You'll learn more about your relationships in a personalised report, and help inform results that we'll publish on BBC.com later this year.

Within a decade, Breslow's team had identified many of the ingredients that we now know are essential for good health: don't smoke; drink in moderation; sleep seven to eight hours a night; exercise; avoid snacks; maintain a moderate weight; eat breakfast. At the time, the findings were so striking that when his colleagues presented the results to him, he believed they were playing some kind of prank. You will hardly need me to explain these guidelines in more detail – the "Alameda 7" are now the basis of most public health guidance.

The research continued, however, and by 1979, two of Breslow's colleagues – Lisa Berkman and S Leonard Syme – had discovered an eighth factor that influenced people's longevity: social connection. On average, the people with the greatest number of ties were around half as likely to die as the people who had smaller networks. The result remained even after they had controlled for factors such as socioeconomic status and people's health at the survey's start, as well as cigarette consumption, exercise and diet.

Getty Images Research on friendship's health benefits can be traced to 1960s California (Credit: Getty Images)Getty Images
Research on friendship's health benefits can be traced to 1960s California (Credit: Getty Images)

Delving deeper, it became clear that all kinds of relationships mattered, but some were more meaningful than others. A sense of connection with spouses and close friends offered the greatest protection, but even casual acquaintances at church or a bowling club helped to stave off the grim reaper.

The sheer audacity of the claim may explain why it was initially neglected in public health guidance. Scientists were used to seeing the body as a kind of machine, largely detached from our mental state and our social environment. But since then, extensive research has confirmed that connection and loneliness influence our susceptibility to many diverse diseases.

The heart of the matter

Social support can boost your immune system and protect you from infection, for instance. In the 1990s, Sheldon Cohen at Carnegie Mellon University in the US asked 276 participants to give full details of their social ties. They were tested for an existing infection, then placed in quarantine and asked to inhale water droplets laced with rhinovirus – the bug behind many coughs and sneezes. Over the following five days, many of the participants went on to develop symptoms, but this was significantly less likely if they had a large and diverse range of social connections. Indeed, those with the lowest levels of social connection had three to four times the risk of developing a cold than those with richer networks of family, friends, colleagues and acquaintances.

Any good scientist should always consider whether other confounding factors might explain the result. It's reasonable to assume that lonely people could be less fit and active, for example, if they spend less time out and about with friends and family. As Berkman and Syme had also discovered, however, the link remained even after the researchers accounted for all those factors. And the size of the effect vastly exceeds the benefits of popping vitamin supplements – another measure we might take to boost our immune system.

Getty Images Having friends could be as good for you as exercise (Credit: Getty Images)Getty Images
Having friends could be as good for you as exercise (Credit: Getty Images)

The social health boost extends to our risk of chronic, life-changing conditions such as type 2 diabetes. This arises when the pancreas stops producing enough insulin, and the body's cells stop responding to the insulin that's flowing through the blood – both of which prevent it from breaking down blood sugar to power cells. Factors such as obesity can contribute to diabetes, but so, it seems, does the quality of your relationships. A study of 4,000 participants in the English Longitudinal Study of Ageing found that a higher score on the UCLA Loneliness Scale – a questionnaire that scientists use to measure social connection – predicted the onset of type 2 diabetes over the following decade. There are even signs that people with stronger social ties have a reduced risk of developing Alzheimer's disease and other forms of dementia.

The strongest evidence, however, concerns cardiovascular diseases. Massive studies tracking the health of tens of thousands of people over many years have repeatedly highlighted the link. This can be seen in the earliest stages – people with poor social relationships are more likely to develop hypertension – and in the worst outcomes, with loneliness increasing the risk of a heart attack, angina or stroke by about 30%.

To get a measure of the social health boost's overall importance, Julianne Holt-Lunstad, a psychologist at Brigham Young University, in Provo, Utah, compiled the findings of 148 studies. Together they covered 300,000 participants and had looked at the benefits of social integration and the hazard of social disconnection. She then compared the effects of loneliness with the risks of various other lifestyle factors, including smoking, drinking alcohol, exercise and physical activity, body mass index (a measure of obesity), air pollution and taking medication to control blood pressure.

The results, published in 2010, were astonishing: Holt-Lunstad found that the size and quality of people's social relationships either equalled or outmatched almost all the other factors in determining people's mortality. The more people feel supported by the people around them, the better their health and the less likely they were to die. Overall, social connection – or its absence – played a larger role in people's health than alcohol consumption, exercise, body mass index and air pollution. Only the effects of smoking came close.

Correlation or causation?

This research has faced critics. For iron-clad proof of a causal link between one lifestyle factor and overall longevity, you'd need to conduct a controlled experiment, in which you randomly allocate people to different conditions. That's how new medicines are tested – some take the pill and others take a placebo, and you then record the different outcomes. In this case, you would have to allocate some people to a loneliness condition, denying them friendships, while others are given a ready-made social network full of loving people. Clearly, this is ethically dubious and practically impossible to do – a fact that has led some people to question whether the apparent effects of social connection are real and significant. They suggest that the scientists might have missed some confounding factor that gives the illusion of a link between our social lives and our health and longevity, despite their best efforts.

Getty Images Loneliness sets off physiological changes in the body that can be damaging in the long-term (Credit: Getty Images)Getty Images
Loneliness sets off physiological changes in the body that can be damaging in the long-term (Credit: Getty Images)

This argument isn't quite as damning as it seems, however, as Holt-Lunstad recently argued in a review of the research. After all, we can't conduct randomised experiments on humans to prove the life-shortening dangers of smoking – the ethics would be even more problematic – but few scientists today would deny the fact that the one causes the other. That's because scientists have other criteria – known as the Bradford Hill guidelines – to demonstrate a causal link between a lifestyle and a disease.

Holt-Lunstad points out that in long-term studies such as the Alameda research, for example, scientists can look for "temporality" – whether someone's lifestyle choice precedes the development of illness. In this case, the sequence is very clear: the people reported their loneliness long before they developed their ill health. Scientists can also look for a "dose–response relationship" – whether greater exposure of the proposed lifestyle factor results in greater risk. Once again, there is a clear pattern – someone who is completely isolated is more likely to suffer worse health than someone who is occasionally lonely, who in turn suffers more illness than someone who has a vibrant social circle.

You can also check whether the findings are consistent across different populations and using different measurement types. If the effects have only been identified in one small sample, or if they only appear when you consider a single loneliness questionnaire, you would be right to be sceptical. But this is not the case.

The social health boost has also now been documented across the world, says Holt-Lunstad, using multiple methods to quantify people's social connections. Whether you are asking for subjective feelings or considering objective facts, such as someone's marital status or the exact number of times they see acquaintances each month, the pattern stays the same. We can even see parallel effects in other social species as diverse as dolphins, chacma baboons and rhesus macaques: the more integrated an individual is within its group, the greater its longevity.

Safety in numbers

To understand how and why the strength of our social ties could influence our health to such a degree, we must consider our evolution. As early humans adapted to living in bigger groups, everything from food supply to protection from predators would have depended on their relationships. To lose standing with companions would have left them in danger of starvation, illness and injury.

Getty Images For early humans, separation from group support was life or death (Credit: Getty Images)Getty Images
For early humans, separation from group support was life or death (Credit: Getty Images)

As a result, the brain and body may have evolved to interpret social isolation as a serious threat. This could be the reason we feel such anguish when we are lonely and disconnected. In much the same way that physical pain warns us to seek out safety and tend to our wounds, social pain may have evolved to persuade us to avoid hostile parties and reestablish our positive relationships.

Feelings of rejection or seclusion also set off a cascade of physiological reactions. In our evolutionary past, these were supposed to protect early humans from the immediate danger posed by isolation, such as attacks from predators or enemies. The brain triggers the release of norepinephrine and cortisol – hormones that keep the mind alert to threats and prepares the body for aggression. The immune system, meanwhile, starts ramping up the production of inflammatory molecules to defend from pathogens. For early humans, this would have reduced the risk of infection if they happened to be injured by an attack. A sense of isolation and social stress can also increase the creation of fibrinogen. This promotes blood clotting and would have helped wounds to heal.

While this response would have increased our chances of short-term survival for our ancestors, it can cause longer-term damage. When the body is constantly prepared for hostility and aggression, it puts extra strain on the cardiovascular system. Chronic inflammation, meanwhile, may prevent wound infection, but the accompanying immune response is less adept at responding to viruses – which would increase the chances of catching a respiratory illness, for example. Chronic inflammation also causes wear and tear on our other cells that can raise the risk of diabetes, Alzheimer's and heart disease. The elevated levels of the clotting factor fibrinogen, meanwhile, can cause thrombosis, which may lead to a heart attack or stroke.

If we spend decades in loneliness and isolation, these changes can drastically raise the risk of illness and early death. When people enjoy connection and social support, however, their bodies will suppress processes such as inflammation. As a result, they will have a much better baseline of health that renders them less susceptible to disease.

As someone who has suffered from shyness, I once found these findings a little disconcerting. How can we reap the benefits of deep connection if we are not naturally gregarious and extroverted? But as I have delved into the evidence, I have discovered that our social skills are like our muscles – the more we use them, the stronger they become. Even self-declared introverts can learn to be more sociable, if they wish.

In much the same way that we plan a fitness regime to boost our physical activity, we can all find ways to integrate more meaningful social interaction in our lives, nurturing old bonds and building new ones. We are wired to connect, if only we provide ourselves with the right opportunities.

* This is an edited extract from the book The Laws of Connection: The Scientific Secrets of Building a Strong Social Network, by David Robson. He is @d_a_robson on X and @davidarobson on Instagram and Threads.

TAKE PART IN A BBC.COM STUDY: We'd like to learn more about your friendships and relationships. If you have five minutes, complete this short anonymous questionnaire and receive a personalised report about your how you interact with others in conversation. We'll analyse and publish the results on BBC.com later this year.

Stroke Survivor Shares Inspirational Story

 There should never be an inspirational stroke story, it should be a common occurrence  of 100% recovery from EXACT STROKE REHAB PROTOCOLS! But that won't occur until we remove all the dead wood in stroke and put survivors in charge.

Stroke Survivor Shares Inspirational Story

It was 10 years ago that Tim Niemann suffered a stroke. He lives now to help others.




Tim Niemann suffered a stroke in November of 2014. Niemann was so impressed and grateful for the care he received at Mercy Hospital that he went on to serve on the board for Mercy Health Foundation St. Louis. | photo by Ursula Ruhl

It was already an unusual day on Nov. 19, 2014, with tensions high as the public awaited a grand jury decision on whether to indict a Ferguson police officer in the fatal shooting of Michael Brown.

Because of this unease, Kirkwood native Tim Niemann, a general partner at Edward Jones, was at home that Wednesday morning instead of traveling for work. 

His wife, Debra Niemann, at home as well, and the two had a conversation before Tim Niemann left the house to return his rental car to the airport. 

As he was leaving the house, Niemann tripped over the couple’s dog and fell. He instantly lost all feeling on the left side of his body, and lost his vision. His wife called 911 and within minutes paramedics arrived and transported Niemann to Mercy Hospital St. Louis.

“Fear didn’t really kick in until I got to the emergency room and watched him quickly deteriorate,” Debra Niemann said.

Within 30 minutes, doctors determined that Niemann, 44 years old at the time, had suffered a stroke. His carotid artery had been unknowingly cut during a recent chiropractic adjustment, causing the stroke(Wrong, a clot from that dissection let go and blocked an artery in the brain. Exactly what happened to me. If our stroke medical personnel can't explain this stuff properly to the media, they shouldn't be there!).

“With a stroke, every minute matters,” said Niemann, now 54. “The good news is they knew what caused it. I wasn’t a victim — I was a survivor.” 

At the hospital, Niemann was given tissue plasminogen activator (tPA) which, when administered within three hours of stroke onset, works by dissolving blood clots that block blood flow to the brain, limiting the risk of damage and impairment. Within minutes of receiving tPA, Niemann’s vision returned and he regained feeling in the left side of his body. 

But the drug isn’t available at all hospitals. In 2021, 65% of hospitals worldwide were unable to provide tPA to their patients, according to the World Stroke Organization.

Niemann was able to walk with assistance just three days after the stroke, and could walk on his own two days after that. He returned to work three months later in February of 2015.

Gratitude

Nearly 10 years later, Niemann has fully recovered from the stroke and works to give back to the community following the life-saving care he received. 

Rather than feel angry or upset, Niemann said he feels lucky to be alive and uses this positive attitude to inspire and better the lives of others. 

“I always had gratitude, but I have a lot more gratitude now,” said Niemann, who lives with his wife and the couple’s four children in Ladue, less than three miles from his childhood home on South Woodlawn in Kirkwood.

Debra Niemann shares her husband’s attitude of gratitude.

“Every day is precious because you never know what’s going to be thrown at you. Appreciate those boring, quiet days,” she said. “Tim listened to his doctors and never got depressed over the state he was in. He was just so happy that he was going to be OK, because it could have been so much worse.”

Both are grateful for the staff, medication and technology at Mercy Hospital.

“I’m so blessed that I happened to be at Mercy. The one really cool thing about the stroke was that I learned how lucky I was,” said Niemann, who attended De Smet Jesuit High School, then St. Louis University and later graduated from Boston College.

Service

Niemann’s positive experience at Mercy inspired him to join the board for Mercy Health Foundation St. Louis following his stroke. He served on the board from 2015 to 2021. 

Mercy President and CEO Steve Mackin said he appreciates Tim Niemann’s service on the board.

“Tim was a tremendous leader on our foundation board and helped guide Mercy through his leadership in many ways,” Mackin said. “He was very willing to share his personal journey with other board members and prospective donors.”

John Mozeliak, former board president and current St. Louis Cardinal’s President of Baseball Operations, echoed that sentiment.

“Tim was inspirational. He focused on something that was personal to him, and his determination was impressive,” Mozeliak said. “Tim’s connection with Mercy will have a lasting impact for years to come.”

In addition to Niemann’s time on the board for Mercy Health Foundation St. Louis, he and his wife helped Mercy Hospital raise $250,000 for the Stroke Campaign, which allowed the hospital to hire two more nurses with specialized training required to quickly help stroke patients. 

“We wanted to figure out what we had to do to recreate the experience I had so everybody is as lucky as me,” Niemann said.

Hoping to inspire others, Niemann has spoken at four Stroke Symposiums, an annual event where larger hospitals in St. Louis meet to share best practices. 

“I try to make the ordinary feel extraordinary for people,” he said. “If a person I know has a stroke, I want to help them be mentally tough and get through it.” 

While Niemann has no lingering physical issues from the stroke, it left him with a heightened sense of fear and uncertainty. 

“Something will happen and I am not sure if it is due to the stroke, or just getting older,” he said.

Jason Selk, former director of sport psychology for the St. Louis Cardinals, has helped Niemann work through his feelings of unease. 

“He told me what he tells professional athletes: ‘If the doctor says you’re good, you’re good,’” Selk said.

Giving & Inspiring Others

After retiring from Edward Jones in 2019 after 31 years with the firm, Niemann now seeks to make a difference in the community by giving time and resources to organizations he supports.

One organization Tim and Debra Niemann are passionate about is the June Jessee Memorial Foundation, which provides relief and support to help children with medically complex neurological conditions. The couple hopes to help open a respite home in St. Louis through the foundation within the next 15 to 20 years. 

Niemann also serves on the board of the Foster & Adoptive Care Coalition, which strives to create permanency in the lives of children by finding foster and adoptive families in the St. Louis area. 

“My wife and I don’t go to bed at night without thinking about trying to find forever homes for these kids,” he said. 

Since his stroke, Niemann’s outlook on life has changed to one that is more focused on helping and listening to others. He views his stroke as the turning point in which he realized the importance of letting people tell their stories, and how lucky he is to be able to hear them.

“My mission is to inspire people to give,” said Niemann. “We all have time, talent or treasure to give.” 

Anna Kuschel, a student at Concordia University Chicago, is a summer intern with the Webster-Kirkwood Times.

MRI Scan Predicts Alzheimer’s Risk Before Symptoms Appear

 Have your doctor analyze the MRI scan you got when entering the hospital to see if it identifies a problem. And then your competent? doctor can initiate those EXACT DEMENTIA PREVENTION PROTOCOLS. But your doctor incompetently doesn't have them, does s/he?

MRI Scan Predicts Alzheimer’s Risk Before Symptoms Appear

Summary: A novel study finds that specialized MRI scans can detect early brain changes that indicate a higher risk for Alzheimer’s disease (AD) before significant cognitive decline occurs. Researchers discovered that cortical microstructural changes in the brain closely resemble patterns seen in AD pathology.

This early detection method could help clinicians identify at-risk individuals and implement preventive strategies sooner. The findings emphasize the importance of early diagnosis for effective treatment.

Key Facts:

  1. Specialized MRI scans detect early brain changes linked to Alzheimer’s risk.
  2. Cortical microstructural changes predict future cognitive decline.
  3. Early identification allows for preventive measures and better treatment outcomes.

Source: Elsevier

Findings from a novel study in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging suggest that using a specialized diffusion weighted MRI scan to monitor the spatial pattern of individual cortical microstructural change in the brain may be a promising approach to characterize individuals who may be vulnerable to developing Alzheimer’s disease (AD) prior to significant cognitive decline and irreversible neuronal damage.

Identifying early markers of AD-related neurodegeneration can fundamentally shift the timeline of risk identification, providing precious time for disease-modifying treatments such as those recently approved by the FDA.

This shows brain scans.
The index of microstructure used comes from an MRI scan and is widely available. Credit: Neuroscience News

First author of the study Rongxiang Tang, PhD, Postdoctoral Scholar, Department of Psychiatry and Center for Behavior Genetics of Aging University of California San Diego, explains, “Our research team previously found that a measure of cortical microstructure, an index of brain grey matter integrity, in cognitively healthy people in their mid-50s can help predict cognitive impairment a decade later.

“So, we were interested in examining if changes in this measure over time are linked to memory changes, and how the spatial patterns of these changes can tell us about a person’s risk of developing cognitive impairment and AD. Tracking these cortical microstructural changes early on in the aging process may be beneficial for early risk identification of cognitive impairment and AD.”

The study included people in their early 60s who live in the community and did not have dementia. Investigators conducted brain assessments twice with MRI scans over a period of five to six years using an index called cortical mean diffusivity that reflects the integrity of grey matter microstructure in the brain.

They then compared how similar these microstructural change brain maps are to those of typical AD pathology deposition (e.g., beta-amyloid and tau) in AD patients from a different study.

Senior author Jeremy A. Elman, PhD, Assistant Adjunct Professor, Department of Psychiatry and Center for Behavior Genetics of Aging, UC San Diego, says, We found that the spatial pattern of microstructural change in our participants closely resembled the typical tau pathology deposition map seen in AD patients. Importantly, the participants whose change maps had greater similarity to the tau map also showed more memory decline over the same time period.

“Because tau is considered to be a major contributor to neurodegeneration (brain shrinkage) and cognitive decline, our results suggest that tracking these cortical microstructural changes and their spatial change patterns early on in the aging process may be beneficial for early identification of risk for cognitive impairment and AD.”

The index of microstructure used comes from an MRI scan and is widely available. It may detect subtle change in the brain before substantial tissue loss has occurred, so even if a person does not yet exhibit significant cognitive problems or brain shrinkage, having a spatial change pattern that looks similar to an AD patient’s spatial pattern of tau accumulation, suggests that they may be experiencing the early stages of AD and are at risk of developing memory problems in the future.

Once identified, clinicians may be able to direct these at-risk people for more in-depth screening and testing such as PET imaging, which can be used for diagnosis by more directly measuring the AD pathology in the brain.

Senior author William S. Kremen, PhD, Professor, Department of Psychiatry and Center for Behavior Genetics of Aging, UC San Diego, says, “Our work, based on the Vietnam Era Twin Study of Aging (VETSA), highlights the value of focusing on non-traditional brain structure measures and on adults as early as midlife in AD research.

“It is remarkable that cortical microstructural changes are earlier and more sensitive to AD-related pathological processes and memory decline than changes in cortical thickness, which are typically used for assessing neurodegeneration/brain shrinkage in AD.”

Editor-in-Chief of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Cameron S. Carter, MD, University of California Irvine, comments, “This work is the first to show that it is not only whether someone is experiencing change in cortical microstructure as measured by MRI that is important, but also the spatial pattern of these changes.

“aying attention to the pattern of changes may help identify people who may be at risk for memory problems and AD in their early 60s, before significant cognitive decline or visible brain shrinkage occurs.”

Based on these findings, clinicians may be able to track a person’s spatial profile of cortical microstructural changes over time to identify if they are at risk of developing cognitive impairment and AD early on in the aging process.

Because AD takes decades to develop, early diagnosis could improve treatment success and patient outcomes.

Moreover, clinicians may recommend risk-reducing intervention or other preventive strategies for people who do not yet have significant AD pathology in the brain but are considered to be at risk based on their diffusion weighted MRI scan based spatial change profile.

About this Alzheimer’s disease and neuroimaging research news

Author: Eileen Leahy
Source: Elsevier
Contact: Eileen Leahy – Elsevier
Image: The image is credited to Neuroscience News

Original Research: Open access.
“Early Cortical Microstructural Changes in Aging Are Linked to Vulnerability to Alzheimer’s Disease Pathology” by William S. Kremen et al. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging


Brain Blood Vessels Key to Combating Cognitive Decline

 Is your competent? doctor checking this out and addressing any needs you might have? NO? So you don't have a functioning stroke doctor, do you?

Brain Blood Vessels Key to Combating Cognitive Decline

Summary: New research highlights the critical role of healthy blood vessels in maintaining brain health and addressing age-related cognitive decline. The study reveals that vascular degradation in the brain can lead to neurodegenerative disorders like Alzheimer’s disease.

Advanced imaging of mice brains showed significant vascular changes with aging, particularly in areas vital for memory and cognitive function. These findings suggest that preserving vascular health could be crucial for preventing cognitive decline.

Key Facts:

  1. Healthy brain blood vessels are essential for preventing cognitive decline.
  2. Vascular degradation can lead to neurodegenerative disorders like Alzheimer’s.
  3. Study used advanced imaging to map brain vascular changes in aging mice.

Source: Penn State

Healthy blood vessels matter for more than just heart health. Vascular well-being is critical for brain health and potentially in addressing age-related cognitive decline and neurodegenerative disorders, like Alzheimer’s disease, according to new study led by Penn State researchers.

The findings point to an understudied but possible key role the brain’s vascular network — or energy infrastructure — plays in the onset of neurodegenerative disease.

They published their work today (July 30) in Nature Communications.

Using advanced imaging techniques, the team developed maps of a mouse brain that illustrate how vascular cells and structures like blood vessels change with age and identified areas that are vulnerable to deterioration.

When blood vessels degrade, nerve cells in the brain, called neurons, are starved of energy, causing them to malfunction or die. It can lead to a condition called vascular dementia, the second leading cause of cognitive impairment in older adults, and symptoms like sleep disturbance.

“With something like Alzheimer’s disease, by the time you can see vascular changes and significant brain shrinkage on a MRI, cell death has already occurred. We need to understand how these cells and structures change before a major catastrophe happens,” said Yongsoo Kim, associate professor of neural and behavioral sciences at Penn State College of Medicine and senior author of the study.

“This study provides early signs of neurodegenerative disorders, potentially leading to earlier diagnosis, and clues for how we can slow down the aging process and cognitive changes.”

According to Kim, aging is one of the primary factors involved in neurodegenerative disorders.

“Yet, we really don’t have a good baseline understanding of how normal aging itself changes the brain, particularly the brain’s vasculature,” Kim said. And with the aging population in the United States growing, he said it’s critical to understand these changes, especially within the network of blood vessels.

Blood vessels, especially micro-vessels, regulate oxygen and energy supply and waste removal to and from neurons. Despite their importance, Kim said, most existing research focuses on how neuron structure and function degenerates over time, rather than the vasculature.

When researchers do study the brain’s vasculature, they’ve primarily examined larger blood vessels or focused on a single, easy-to-access region of the brain, the somatosensory cortex.

More importantly, typical neuroimaging techniques, like MRI, don’t provide high enough resolution to see what’s happening in the tiny blood vessels, which make up 80% to 85% of the brain’s vasculature, according to Kim.

Kim and the research team produced a detailed map of the vascular network of the whole mouse brain using two high-resolution 3D mapping techniques: serial two-photon tomography — a technique that creates a series of stacked 2D images — and light sheet fluorescence microscopy, which images intact 3D samples to visualize the whole brain at a single cell-resolution.

They imaged the brains of young and old mice to chart vasculature changes across the brain with normal aging.

“Because we’re doing high-resolution mapping with the sufficient resolution, we can reconstruct the whole vascular structure and scan the entire brain to pinpoint areas that undergo selective degeneration with age,” Kim said.

“What we found is that the area that most people study showed the least amount of change, whereas profound change happens in areas in the deep areas of the brain. This suggests that we’ve been looking at the wrong area when it comes to aging studies.”

The images showed that changes in the vascular network don’t occur equally across the brain. Rather, they were concentrated in the basal forebrain, deep cortical layers and hippocampal network, suggesting these areas are more vulnerable to vascular degeneration. These regions play a role in attention, sleep, memory processing and storage, among other functions.

As brains age, vascular length and branching density decreases approximately 10%, indicating that there’s a sparser network to distribute blood. Arteries in older brains also appear more twisted compared to those in younger brains, which can impede blood flow, especially to areas further away from the main arteries like the deep cortical layers, Kim explained.

The team also examined functional changes of vasculature and found that the system responds more slowly in older brains. That means that it can’t provide the neurons with energy as quickly and readily as the cells may need.

There’s also a loss of pericytes, a type of cell that regulates blood supply and blood vessel permeability, too. As a result, the blood vessels become “leaky,” compromising the blood-brain barrier.

This study builds on the group’s previous research, where they mapped the vasculature of a young mouse brain. Next, they are studying how Alzheimer’s disease-induced changes in the brain influences vascular health and neuronal function. Ultimately, they said they hope their work will lead to treatments for neurodegenerative disorders.

Hannah Bennett, dual medical degree and doctoral degree student, and Steffy Manjila, postdoctoral scholar, co-led the study along with Quingguang Zhang, who was assistant research professor at Penn State at the time of the research and is currently assistant professor at Michigan State University, and Yuan-ting Wu, who was previously research scientist at Penn State and currently project scientist at Cedars-Sinai Medical Center. Other Penn State authors on the paper include: Patrick Drew, professor of engineering science and mechanics, of neurosurgery, of biology and of biomedical engineering and interim director of the Huck Institutes of the Life Sciences; Uree Chon, research technician; Donghui Shin, research technologist; Daniel Vanselow, research project manager; Hyun-Jae Pi, data scientist.

Funding: The National Institutes of Health and the American Heart Association funded this work. 

About this neuroscience research news

Author: Christine Yu
Source: Penn State
Contact: Christine Yu – Penn State
Image: The image is credited to Neuroscience News

Original Research: Open access.
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain” by Yongsoo Kim et al. Nature Communications

New risk calculator may reduce number of patients suggested for BP-lowering medication

 You'll have to ask your competent? doctor if this changes anything about your blood pressure interventions.

New risk calculator may reduce number of patients suggested for BP-lowering medication

Key takeaways:

  • Those with stage 1 hypertension had lower 10-year ASCVD risk when estimated using new PREVENT equations.
  • Use of PREVENT rather than the Pooled Cohort Equations may reduce antihypertensive drug use as a result.

Ten-year atherosclerotic CVD risk for people with stage 1 hypertension was substantially lower when estimated with the new PREVENT equations vs. the Pooled Cohort Equations, researchers reported.

This finding may indicate that fewer patients assessed using the PREVENT equations would be subsequently prescribed antihypertensive medication for primary prevention, according to research published in Hypertension, though the researchers suggested that 30-year risk can be included in such decisions.

Doctor reviewing medical chart_Shutterstock
Those with stage 1 hypertension had lower 10-year ASCVD risk when estimated using new PREVENT equations. Image: Adobe Stock

“Many people may not have a heart attack or stroke, or develop heart failure in the next few years, yet they may benefit from lowering their blood pressure to protect them against having a heart attack, stroke or heart failure later in life,” Paul Muntner, PhD, MHS, FAHA, visiting professor in the department of epidemiology at the University of Alabama at Birmingham, said in a press release. “Experts who develop cardiovascular disease guidelines may want to consider both near-term risk and lifetime risk for having heart disease, stroke and heart failure in lifestyle changes and treatment recommendations.”

The new PREVENT equations

The American Heart Association first unveiled its new PREVENT equations to predict long-term absolute risk tied to CV-kidney-metabolic syndrome at its Scientific Sessions in November.

As Healio previously reported, the PREVENT equations were developed using real-world contemporary data from more than 6 million adults and include HF risk in addition to risk for MI and stroke; omit race from CVD clinical care algorithms; include kidney function on top of traditional CVD risk factors for heart disease; and include social determinants of health, glucose and kidney function, when clinically available.

When used at age 30 years, the equations are designed to enable 10- and 30-year total CV risk estimation and aid clinical decision-making.

“Higher systolic BP levels increase the risk of heart failure, an outcome not included in the Pooled Cohort Equations. Also, the Pooled Cohort Equations were developed using data from the 1980s to the 2000s and may not correctly estimate risk in contemporary cohorts,” the researchers wrote in the study background.

Paul Muntner

For the present study, Muntner and colleagues used National Health and Nutrition Examination Survey data from 2013 to 2020 from 1,703 adults (mean age, 50 years; 55% men) to assess 10-year ASCVD risk estimated using the Pooled Cohort Equation compared with 10-year ASCVD and total CVD risk estimated by the PREVENT equations.

Participants were without self-reported CVD at baseline, and all had stage 1 hypertension, defined as systolic BP of 130 mm Hg to 139 mm Hg or diastolic BP of 80 mm Hg to 89 mm Hg.

The average 10-year ASCVD risk was 5.4% when researchers used the Pooled Cohort Equations and 2.9% with the PREVENT equations.

With the Pooled Cohort Equations, the proportion of participants with a 10-year ASCVD risk of 10% to less than 15% was 8.1%, and 7.8% had a risk of at least 15%. In comparison, 3% had a 10-year ASCVD risk of 10% to less than 15% when using the PREVENT equations, and only 0.3% had a risk of at least 15%.

The researchers noted that no participants had both a 10-year ASCVD risk of 10% or more on the PREVENT equations and a risk less than 10% on the Pooled Cohort Equations. However, 12.5% had a 10-year ASCVD risk of 10% or more on the Pooled Cohort Equations and a less than 10% risk on the PREVENT equations.

Moreover, the average 10-year total CVD risk was lower with the PREVENT equations compared with the Pooled Cohort Equations across all subgroups.

Antihypertensive initiation may decline for some

“The current study has potential implications for clinical practice and public health,” the researchers wrote. “In the current study, a substantially smaller percentage of U.S. adults with stage 1 hypertension had 10-year predicted ASCVD risk 10% when estimated by the PREVENT equations vs. the Pooled Cohort Equations. ... This indicates that fewer U.S. adults with stage 1 hypertension may be recommended antihypertensive medication initiation if 10-year predicted ASCVD risk was estimated using the PREVENT equations instead of the Pooled Cohort Equations.

“The PREVENT equations demonstrated good calibration for ASCVD and total CVD risk in contemporary cohorts, suggesting that U.S. adults with 10-year predicted ASCVD and CVD risk < 10% should have low event rates,” they wrote.

However, Muntner said in the release: “Many people with stage 1 high blood pressure who are not likely to have a heart attack, stroke or heart failure over the next 10 years may have a high risk over the next 30 years. People may want to discuss this with their doctors and consider starting antihypertensive medication to reduce their risk of heart attack, stroke and heart failure across their lifetime even if they have a low short-term risk.”

Reference:


Sources/Disclosures

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Disclosures: One author reports being the founder of MedExplain. Muntner and the other authors report no relevant financial disclosures.

Sheridan suffered a stroke after a massage. Now she's suing the masseuse for negligence

 Of course there was negligence, the masseuse did nothing to determine the stiffness of her neck arteries similar to chiropractic strokes!

This is precisely why you NEVER get your neck adjusted. Your masseuse/chiropractor has no clue how stiff your arteries are and whether there is plaque in them ready to be torn free. Has your masseuse/chiropractor calculated the physics and knows EXACTLY the force not to rip the arteries or plaque apart?

For a brief period of time, chiropractic applies 58% to 87% of the force of a suspended hanging. Do not listen to your masseuse/chiropractor pooh-poohing this risk.

You and your masseuse/chiropractor are making the assumption with no knowledge that your cervical arteries running thru your spine are flexible enough and contain no plaque that they will withstand the adjustment.  How do you know that is the case?

Calculations here:

Chiropractic force

Chiropractic apologist here for their side of the story, equal opportunity and all: 

DEBUNKED: The Odd Myth That Chiropractors Cause Strokes Revisited (Wow! What balderdash!)

The latest here:

Sheridan suffered a stroke after a massage. Now she's suing the masseuse for negligence

In short:

A Geelong mother of four is suing a masseuse and a medical clinic claiming a remedial massage she received in 2019 caused her to suffer a stroke.

Sheridan Digby has lodged a statement of claim with Victoria's Supreme Court.

What's next?

The masseuse has denied they did not use reasonable care during Ms Digby's treatment, and says they will vigorously defend themselves against the claim.

Sheridan Digby had hoped a 2019 remedial massage appointment would help fix her sore neck.

Instead, she says it caused her to suffer a stroke.

The Geelong mother of four is now preparing to front the Supreme Court of Victoria, where she will claim the masseuse and medical clinic where she received the massage are liable for her injuries.

In a statement of claim lodged with the courts, Ms Digby alleges that the massage therapist said they wanted to "really piss the muscles off" with a deep and forceful massage to the back of her neck.

Geelong mum Sheridan Digby standing indoors next to a window, looking out into sunlight with a neutral expression
Ms Digby's statement of claim argues the massage "caused or contributed" to her stroke.(ABC News: Harrison Tippet)

Her claim alleges the massage caused or contributed to tears to the inner walls of both her vertebral arteries — running up either side of the back of the spine — which then led to a stroke.

"It felt like I'd been hit by a truck," Ms Digby told the ABC.

"It just felt like everything was thrown out of whack. I couldn't concentrate, I lost my balance, I couldn't see, I had no energy, fatigue."

While Ms Digby has now regained some of the vision lost on her left side, she said the constant fatigue has had a lingering impact on her life, particularly as the sole parent of four kids.

"It's like an invisible illness," she said.

"People don't automatically look at you and assume you've had a stroke because you're not paralysed on one side, but it doesn't mean that you don't feel terrible on the inside.

"Having less vision makes everything harder, having fatigue makes everything harder. Every single thing in your life just becomes a little bit more difficult. And people don't notice."

Defence documents show the masseuse denies they did not use reasonable care during the treatment on Ms Digby, and denies the allegation they said they wanted to "really piss the muscles off". The medical clinic has also denied liability for Ms Digby's injuries.

In a statement to the ABC, the masseuse said they held an "excellent long-term record" after decades as a remedial massage therapist.

"I am extremely disappointed that this claim has been made against me and deny the allegations outright," they said.

"I feel for the person making the claim and wish her well, but I will be vigorously defending myself in relation to this claim."

"I am absolutely confident the expert evidence will prove that I did not cause the injuries alleged."

Limited research on link between massage and stroke

While Ms Digby's legal challenge and the subsequent denials may be straightforward, the link between massages and strokes is less so.

There is limited research and medical evidence linking massages with strokes, largely due to the rarity of the injury.

However, a leading expert who spoke to the ABC said they believed it was possible.

Victor Chang Cardiac Research Centre Director Professor Jason Kovacic sitting inside, reading a printed report
Victor Chang Cardiac Research Centre Director Jason Kovacic says it is possible a massage could cause a stroke.(ABC News: Keana Naughton)

Victor Chang Cardiac Research Centre Director and CEO Jason Kovacic said the connection between the two was the creation of an arterial dissection to either the vertebral arteries running along the back of the spine, or carotid arteries on either side of the neck.

An arterial dissection can create a clot at the point of the arterial wall tear, with the clot either blocking blood flow or dislodging and causing a stroke.

Professor Kovacic said while arterial dissections were rare, and those caused by massages even more rare, it did not mean they didn't happen.

"Certainly, a massage is a less common precipitant of a dissection, certainly more forceful and violent things like a severe car whiplash injury would be a more common triggering event for a dissection," Professor Kovacic said.

"But could a massage in theory cause a dissection? I think it could if it was forceful enough.

"Unfortunately, we are limited in the data as to what's available to us to interpret all of this, but nevertheless the link between violent neck movements or extreme neck movements and carotid and vertebral arterial dissection events is quite clear."

Victor Chang Cardiac Research Centre Director Professor Jason Kovacic wearing a white coat in a lab, looking at a test tube
Professor Kovacic said he knew of many patients who experienced great benefits from massages.(ABC News: Keana Naughton)

Professor Kovacic stressed that he did not oppose massage treatments.

"I would say that I have a lot of patients that derive enormous value from massage, and I think massaging in competent hands can be a wonderfully therapeutic thing and I fully endorse it," he said.

The American Stroke Association (ASA) in 2014 released a statement for healthcare professionals regarding the link between cervical arterial dissections and manipulative therapies on the neck, noting that arterial dissections were an "important cause" of strokes in younger people.

The paper concluded that: "Although current biomechanical evidence is insufficient to establish the claim that Cervical Manipulative Therapy (CMT) causes Cervical Artery Dissections (CD), clinical reports suggest that mechanical forces play a role in a considerable number CDs of and most population controlled studies have found an association between CMT and Vertebral Artery Dissection stroke in young patients"

The paper also suggested practitioners should inform patients of "the statistical association between CD and CMT prior to undergoing manipulation of the cervical spine".

The ABC has contacted the ASA for further comment, while the Australian Stroke Foundation declined to comment.

The Alfred, Austin and Royal Melbourne Hospitals all declined to comment on how often they receive patients suffering arterial dissections or strokes shortly following massage or neck treatments.

Stroke survivor still suffering fatigue, depression six years on

Mornington Peninsula father of two Paul Burns was also found to have suffered an arterial dissection before his 2018 stroke.

Stroke survivor Paul Burns standing in a dark room, wearing a knitted jumper and reading glasses, looking directly at the camera
 Paul Burns suffered a stroke just hours after a 2018 massage treatment

He believes that dissection was directly linked to a myotherapy appointment he had received earlier that day.

"I had to teach myself how to walk again, how to eat again, how to swallow food again," Mr Burns said.

Post-stroke fatigue is one of the biggest lingering impacts of stroke Mr Burns faces today, along with "a loss of identity".

A close up shot of stroke survivor Paul burns, facing away from the camera, showing a long scar down the back of his head
Paul Burns still bears the scars of his 2018 stroke

"That's still a day-to-day challenge, working out who I am and what I'm doing and why it matters … a lot of depression comes with that," he said.

The impact on Paul's two young children, one of whom was only a baby when he suffered his stroke, is the most painful aspect of his injury.

"My eldest will have a little bit of a grasp on it, but my youngest will never know me at my best," he said.

"He'll never know me pre-injury … and I will always have massive regrets over that."

A self-regulated industry

Victorian massage therapists operate under a negative licensing model, meaning anyone can call themselves a massage therapist in what is a largely self-regulated industry.

The practice is classed as a general health service, with no provision in the Health Act requiring practitioners to be registered.

All Victorian health professionals are nonetheless subject to a range of laws, including the general code of conduct set out in the Health Complaints Act — which leaves massage therapists open to prohibition orders from Victoria's Health Complaints Commissioner (HCC).

Last financial year, the HCC issued 18 prohibition orders against seven different massage therapists.

The Association of Massage Therapists (AMT), a national not-for-profit group aiming to advance the profession, argues the negative licensing model "does not provide adequate protection to members of the public".

In a position statement, the AMT said it supported the creation of a uniform national framework to create credentials for massage therapists, and the protection of the title 'Massage Therapist' to safeguard the public "from rogue or unqualified practitioners".

Jupiter Medical Center is Nationally Recognized for its Commitment to Providing High-Quality Stroke Care

 

I wouldn't go there if all they are offering is 'care'; NOT RECOVERY!

Anytime I see 'care' in any stroke press release I know the stroke medical world is not willing to disclose actual results because they are so fucking bad, it wouldn't look good, so misdirection is used. Don't fall for that misdirection! By touting 'care' they are not telling you about results or recovery which survivors want! Survivors don't care about your 'care'; you FUCKING BLITHERING IDIOTS; they want 100% recovery! Why aren't you providing that?

Big fucking whoopee.

 

 But you tell us NOTHING ABOUT RESULTS. They remind us they 'care' about us multiple times but never tell us how many 100% recovered.  You have to ask yourself why they are hiding their incompetency by not disclosing recovery results.  ARE THEY THAT FUCKING BAD?


Three measurements will tell me if the stroke medical world is possibly not completely incompetent; DO YOU MEASURE ANYTHING?  I would start cleaning the hospitals by firing the board of directors, you can't let incompetency continue for years at a time.

There is no quality here if you don't measure the right things.

  1. tPA full recovery? Better than 12%?
  2. 30 day deaths? Better than competitors?
  3. rehab full recovery? Better than 10%?

 

You'll want to know results so call that hospital president(whomever that is) RESULTS are; tPA efficacy, 30 day deaths, 100% recovery. Because there is no point in going to that hospital if they are not willing to publish results.

In my opinion this partnership allows stroke hospitals to continue with their tyranny of low expectations and justify their complete failure to get survivors 100% recovered. Prove me wrong, I dare you in my stroke addled mind. If your stroke hospital goal is not 100% recovery you don't have a functioning stroke hospital.

 

All you ever get from hospitals are that they are following guidelines; these are way too static to be of any use. With thousands of pieces of stroke research yearly it would take a Ph.D. level research analyst to keep up, create protocols, and train the doctors and therapists in their use. 

If your stroke hospital doesn't have that, you don't have a well functioning stroke hospital, you have a dinosaur. 

Read up on the 'care' guidelines yourself. Survivors want RECOVERY not 'care'

“What's measured, improves.” So said management legend and author Peter F. Drucker 

The latest invalid chest thumping here:

Jupiter Medical Center is Nationally Recognized for its Commitment to Providing High-Quality Stroke Care

Jupiter Medical Center has received the American Heart Association’s Get With The Guidelines® – Stroke Gold Plus quality achievement award for its commitment to ensuring stroke patients receive the most appropriate treatment according to nationally recognized, research-based guidelines, ultimately leading to more lives saved and reduced disability.

Stroke is the No. 5 cause of death and a leading cause of disability in the U.S., and early stroke detection and treatment are key to improving survival, minimizing disability, and accelerating recovery. As a Joint Commission Certified Thrombectomy-Capable Stroke Center, the stroke program at Jupiter Medical Center meets rigorous standards indicative of the highest level of stroke  care(NOT RECOVERY!), combining speed, innovation, and expertise to provide comprehensive  care(NOT RECOVERY!) for stroke.

“At Jupiter Medical Center, our state-of-the-art Stroke Center is equipped with sophisticated technology to diagnose, intervene, and treat strokes quickly,” states Dr. Amit Rastogi, MD, MHCM, President, and CEO of Jupiter Medical Center. “We strive to provide seamless and exceptional patient  care(NOT RECOVERY!) through collaboration with world-class physicians, emergency responders, dedicated stroke coordinators, and rehabilitation therapists.”

Get With The Guidelines – Stroke is an in-hospital program for improving stroke  care(NOT RECOVERY!) by promoting consistent adherence to the latest research- and evidence-based guidelines, which can minimize the long-term effects of a stroke and even prevent death. Hospitals receiving a Gold Plus Achievement have reached an aggressive goal of treating stroke patients with high compliance to levels of  care(NOT RECOVERY!) outlined by the American Heart Association/American Stoke Association.

Each year, program participants qualify for the award by demonstrating their commitment to providing quality  care(NOT RECOVERY!) for stroke patients. In addition to following treatment guidelines, Get With The Guidelines participants also educate patients to help them manage their health and recovery at home.

“We are incredibly pleased to recognize Jupiter Medical Center for its commitment to caring for patients with stroke,” said Steven Messe, M.D., volunteer chairperson of the American Heart Association Stroke System of  care(NOT RECOVERY!) Advisory Group and professor of neurology and director of fellowships of neurology at the Hospital of the University of Pennsylvania. “Participation in Get With The Guidelines is associated with improved patient outcomes, fewer readmissions and lower mortality rates – a win for health  care(NOT RECOVERY!) systems, families and communities.”

Jupiter Medical Center also received two additional recognitions from the American Heart Association, Target: StrokeSM Honor Roll Elite Plus award, and Target: Type 2 Diabetes™ Honor Roll award. The recognition follows the latest U.S. News & World Report recognition which named Jupiter Medical Center a 2024-2025 high-performing hospital for Stroke and 8 additional disciplines.

For more information about Jupiter Medical Center, visit jupitermed.com, call (561) 263-2234, or follow Jupiter Medical Center on Facebook and Instagram @jupitermedicalcenter or on Twitter @JupiterMedCtr.

 

ABOUT JUPITER MEDICAL CENTER
Rated #1 in the region for quality, safety, and patient experience, Jupiter Medical Center is the leading destination for world-class health care(NOT RECOVERY!) in Palm Beach County and across the Treasure Coast. Jupiter Medical Center’s state-of-the-art facilities and leading-edge technologies enable its award-winning physicians to provide a comprehensive continuum of inpatient and outpatient health  care(NOT RECOVERY!) services. Jupiter Medical Center’s specialty centers of excellence include: comprehensive cancer care, cardiovascular care, orthopedics, neurosciences, and women’s and children’s services. For more information about Jupiter Medical Center, please call 561-263-2234 or visit www.jupitermed.com.

ABOUT GET WITH THE GUIDELINES®

Get With The Guidelines® is the American Heart Association/American Stroke Association’s hospital-based quality improvement program that provides hospitals with the latest research-based guidelines. Developed with the goal of saving lives and hastening recovery, Get With The Guidelines has touched the lives of more than 14 million patients since 2001. For more information, visit heart.org.