Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, August 20, 2025

Metformin Use Linked to Lower Risk for Dementia, Death in Adults With Overweight, Obesity

 

Well, since this has been around for years why the hell doesn't someone actually create protocols on stroke recovery? Why, because there aren't two functioning neurons anywhere in the stroke medical world!

Earlier research has this line:The drug, which is cheaply available for just $0.16 a day, works by boosting the number of oxygen molecules released into a cell, which in turn seems to benefit the robustness and longevity of the body’s basic building blocks. (This would seem to be much easier and faster than HBOT. I'm requesting this at my next stroke, my doctor won't know what hit her when I tell her how to treat me.)

If your doctor doesn't know about this s/he IS COMPLETELY FUCKING INCOMPETENT? And not creating protocols is even worse, allowing millions to billions of neurons to die because of lack of oxygen during the neuronal cascade of death!

 

Metformin Use Linked to Lower Risk for Dementia, Death in Adults With Overweight, Obesity

During 10 years of follow-up, metformin users showed significantly lower risks for both dementia and all-cause mortality vs controls.
HealthDay News  Metformin use is associated with lower risks for dementia and all-cause mortality across body mass index (BMI) groups in patients with overweight or obesity, according to a study published online Aug. 6 in Diabetes, Obesity and Metabolism.

Yu-Liang Lin, M.D., from Taipei Medical University in Taiwan, and colleagues conducted a multicenter cohort study to investigate whether metformin use was associated with a lower long-term incidence of dementia and all-cause mortality in patients with overweight or obesity. The analysis included electronic health record data from the TriNetX network, consisting of 132,920 patients with a BMI of 25 to 29.9 kg/m2, 142,723 with a BMI 30 to 34.9 kg/m2, 94,402 with a BMI of 35 to 39.9 kg/m2, and 82,732 with a BMI >40 kg/m2. Propensity score matching was used to compare adults in each BMI group prescribed metformin to matched controls who were not prescribed metformin.

The researchers found that during 10 years of follow-up, metformin users showed significantly lower risks for both dementia and all-cause mortality versus controls. Risk for dementia was lower across each BMI group (hazard ratios [HRs], 0.875, 0.917, 0.878, and 0.891, respectively). A similar trend was seen for the risk for all-cause mortality (HRs, 0.719, 0.727, 0.717, and 0.743, respectively).

“In this large, multicenter cohort study, metformin use was associated with reduced risks of dementia and all-cause mortality in obese patients. The protective effect was observed across all BMI groups, with variations noted by population,” the authors write. “These findings support the potential of metformin in lowering dementia risk in patients with obesity. Further studies are needed to explore the underlying mechanisms.”

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