While I was browsing thru Dr. Steenblocks site and his religious belief in HBOT I saw iron deposition. This article discusses it as a possible factor in cell death following a stroke. I couldn't see where it actually proposes a way to prevent that unless the purchased article says something. I really wish researchers would say what they mean in 8th grade terms, they should be smart enough to be able to convey their meaning to those less smart than them.
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6X1H-4CJVR53-1&_user=10&_coverDate=07%2F31%2F2004&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_searchStrId=1734337935&_rerunOrigin=google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=004bdd0b5bd897661e0afdd5418e2ee3&searchtype=a
The role of iron neurotoxicity in ischemic stroke
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Magdy H. Selim, , a and Rajiv R. Ratan, b, 1
a Department of Neurology, Division of Cerebrovascular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Palmer 127, Boston, MA 02215, USA
b Burke/Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY, USA
Received 6 April 2004; accepted 6 April 2004. Available online 7 June 2004.
Abstract
Stroke is the second leading cause of death worldwide, and its incidence is expected to rise with the projected increase in the number of aging population. Disturbances of brain iron homeostasis have been linked to acute neuronal injury following cerebral ischemia. Free iron catalyzes the conversion of superoxide and hydrogen peroxide into hydroxyl radicals, which promote oxidative stress leading to subsequent cell death/apoptosis. In recent years, considerable evidence has emerged regarding the role of iron neurotoxicity following experimental cerebral ischemia. Few clinical studies have also attempted to investigate the role of iron in stroke patients. The present review will examine the currently available evidence for iron-mediated neurotoxicity and the potential mechanisms underlying deregulation of iron homeostasis in the brain following cerebral ischemia. Understanding the changes in brain iron metabolism and its relationship to neuronal injury in ischemic stroke could provide new therapeutic targets to improve the outcome of stroke patients.
Author Keywords: Ferric; Ferrous; Stroke; Ischemia; Hypoxia; Neuronal
Article Outline
1. Iron homeostasis is important for normal brain function
2. The link between iron and ischemic stroke
3. Evidence for iron involvement in ischemic neuronal injury
3.1. Animal data
3.2. Clinical data
4. Source(s) of released iron in the brain after ischemic stroke
5. The relationship between brain iron load and severity of neuronal damage after stroke
6. Temporal profile of iron-mediated neuronal injury after ischemic stroke
7. Summary
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