What is your doctor doing to make sure this happens? And if your doctor doesn't know what oligodendrocytes do then you have an idiot for a doctor?
Ruilan Zhang1, Michael Chopp1,2 and Zheng Gang Zhang1*
- 1Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
- 2Department of Physics, Oakland University, Rochester, MI, USA
Neural stem cells in the subventricular zone (SVZ) of the lateral
ventricle of adult rodent brain generate oligodendrocyte progenitor
cells (OPCs) that disperse throughout the corpus callosum and striatum
where some of OPCs differentiate into mature oligodendrocytes. Studies
in animal models of stroke demonstrate that cerebral ischemia induces
oligodendrogenesis during brain repair processes. This article will
review evidence of stroke-induced proliferation and differentiation of
OPCs that are either resident in white matter or are derived from SVZ
neural progenitor cells and of therapies that amplify endogenous
oligodendrogenesis in ischemic brain.
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