Deans' stroke musings: Wall Shear Stress Distribution of Small Aneurysms Prone to Rupture: A Case-Control Study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, December 2, 2013

Wall Shear Stress Distribution of Small Aneurysms Prone to Rupture: A Case-Control Study

Your doctor should be able to look at your other aneurysms and determine the best course of action to prevent them rupturing; clipping, coiling, gluing.
http://www.docguide.com/wall-shear-stress-distribution-small-aneurysms-prone-rupture-case-control-study?hash=7e422beb&eid=36167&alrhash=3c9ebc-5aeefe0d7ed0a73e6788dca4998df39c

Bouillot P, Narata A, Schaller K, Lovblad K, Ouared R; Stroke (Nov 2013)

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Vascular Disorders

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BACKGROUND AND PURPOSE Subarachnoid hemorrhage after intracranial aneurysm rupture remains a serious condition. We performed a case-control study to evaluate the use of computed hemodynamics to detect cerebral aneurysms prone to rupture.
METHODS Four patients with incidental aneurysms that ultimately ruptured (cases) were studied after initially being included in a prospective database including their 3-dimensional imaging before rupture. Ruptures were located in different arterial segments: M1 segment of the middle cerebral artery; basilar tip; posterior inferior cerebellar artery; and anterior communicating artery. For each case, 5 controls matched by location and size were randomly selected. An empirical cumulative distribution function of aneurysm wall shear stress percentiles was evaluated for every case and used to define a critical prone-to-rupture range. Univariate logistic regression analysis was then used to assess the individual risk of rupture.
RESULTS A cumulative wall shear stress distribution characterizing a hemodynamic prone-to-rupture range for small-sized aneurysms was identified and fitted independent of the location. Sensitivity and specificity of the preliminary tests were 90% and 93%, respectively.
CONCLUSIONS The wall shear stress cumulative probability function may be a potential predictor of small-sized aneurysm rupture.