This article gives a different view of NO - nitric oxide. You'll have to ask your doctor which one is correct for you. Breathing exercises create nitric oxide which relaxes the arterial walls lowering your blood pressure
Researchers discover new ways to shut down signals involved in brain diseases
A research team based at the University of Eastern Finland and the
Turku Centre for Biotechnology have found new ways to block a pathway
that may be responsible for several brain disorders, which could open
the door to developing better treatments.
The protein NOS-1 generates
nitric oxide, a chemical signal that is linked to neurological
disorders from neurodegeneration, stroke and chronic pain sensitivity to
anxiety and depressive disorders. These are now among the most common
causes of disability and mortality, but decades of efforts have not led
to a safe drug that controls NOS-1.
The researchers involved in
the new work previously found that neurodegeneration or brain lesions
caused by NOS-1 requires it to bind another protein called NOS1AP (or
CAPON). They asked if damage can be reduced by preventing binding of
NOS1AP to NOS-1, as NOS-1 cannot directly be controlled by drugs.
The
researchers now reveal NOS1AP binds to NOS-1 in a surprisingly complex
manner, and developed two separate ways to prevent it. By studying
precisely how NOS1AP binds to NOS-1 they found two separate sites of
interaction, by demonstrating that two different parts of NOS1AP are
required for binding to
NOS-1 on separate sites. Each site could
be blocked, one by a peptide previously developed by the team and the
other by a new synthetic protein generated for this study. The second
site was completely unexpected as no similar interaction had been
previously described and so nobody had known to look for it before.
Blocking either site by itself reduced the damaging signals caused by
NOS1 in brain cells. The results were replicated in several regions of
brain tissue that are sensitive to degeneration caused by NOS-1. This
means that it is now easier to design drugs that control damaging
signals from NOS-1 in the brain because it can be done in two different
ways or both ways may be combined. This might lead to development of new
drugs for several different neurological diseases and conditions.
This
research, published in the 13th May issue of the Journal of
Neuroscience, was funded by the Academy of Finland, the European Union,
the University of Eastern Finland, The Finnish Cultural Foundation North
Savo Regional Fund, The Magnus Ehrnrooth Foundation and the University
of Turku. The researchers hope that continuation of their work could
lead to improved treatments for neurological conditions such as stroke
and chronic pain as well as depressive and anxiety disorders. As NOS1AP
and NOS-1 are associated with schizophrenia and sudden cardiac death,
future research in this area may even assist the treatment of a wider
range of diseases.
http://www.btk.fi/research/affiliated-groups/courtney-michael-neuronal-signal-pathways/
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