Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, January 19, 2017

History of Neuroprotection: Trials and Tribulations

By using this neutral name rather than an action causing name like the neuronal cascade of death, you are basically saying this is not really a problem for stroke survivors.  I do wonder if they have analyzed the reasons that 1000+ neuroprotective trials have failed as stated by  Dr. Michael.Tymianski@uhn.ca
Nothing here gives any sense of urgency because we don't know how much less than 1.9 million neurons are dying every minute. Any continuing death of neurons needs to be stopped. Neuroprotection gives NO sense of urgency. I bet they don't even know how long the neuronal cascade of death continues after the blockage or bleed is stopped.
http://link.springer.com/chapter/10.1007/978-3-319-45345-3_5
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Abstract

Neuroprotection is a strategy of interference, antagonism, and slowing down the sequence of molecular pathophysiological processes eventually resulting in irreversible cerebral ischemia. Over the past two decades, neuroprotection in ischemic stroke has emerged as a central topic of intense experimental animal studies and clinical trials in humans. Although rigorous animal studies have provided the proof of principle that neuroprotection is achievable, the novel agents and mechanisms investigated in human clinical trials have consistently failed to demonstrate a significant beneficial effect. Here we survey key neuroprotective trials and consider the strengths and shortcomings of these studies. Agents and mechanisms considered include calcium channel blockers, glutamate antagonists, GABA agonists, antioxidants and free radical scavengers, nitric oxide signal-transduction, modulation of inflammation, hemodilution, hypothermia, albumin therapy, and magnesium therapy. These human trials of neuroprotection therapies have been disappointing, unlike successful acute stroke approaches using reperfusion therapies such as thrombolytics or clot-retrieving devices. We highlight how improved clinical trial design and translational strategies and lessons learned from these negative trials will guide future directions including better clinical trial design and patient selection, multiple agent-combination therapies, and pre-hospital intervention.

159 references at the link which your doctor should know all about.

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