Nothing here gives any sense of urgency because we don't know how much less than 1.9 million neurons are dying every minute. Any continuing death of neurons needs to be stopped. Neuroprotection gives NO sense of urgency. I bet they don't even know how long the neuronal cascade of death continues after the blockage or bleed is stopped.
http://link.springer.com/chapter/10.1007/978-3-319-45345-3_5
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Abstract
Neuroprotection is a
strategy of interference, antagonism, and slowing down the sequence of
molecular pathophysiological processes eventually resulting in
irreversible cerebral ischemia. Over the past two decades,
neuroprotection in ischemic stroke has emerged as a central topic of
intense experimental animal studies and clinical trials in humans.
Although rigorous animal studies have provided the proof of principle
that neuroprotection is achievable, the novel agents and mechanisms
investigated in human clinical trials have consistently failed to
demonstrate a significant beneficial effect. Here we survey key
neuroprotective trials and consider the strengths and shortcomings of
these studies. Agents and mechanisms considered include calcium channel
blockers, glutamate antagonists, GABA agonists, antioxidants and free
radical scavengers, nitric oxide signal-transduction, modulation of
inflammation, hemodilution, hypothermia, albumin therapy, and magnesium
therapy. These human trials of neuroprotection therapies have been
disappointing, unlike successful acute stroke approaches using
reperfusion therapies such as thrombolytics or clot-retrieving devices.
We highlight how improved clinical trial design and translational
strategies and lessons learned from these negative trials will guide
future directions including better clinical trial design and patient
selection, multiple agent-combination therapies, and pre-hospital
intervention.
159 references at the link which your doctor should know all about.
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