Deans' stroke musings: Clot-busting drugs for ischemic stroke when the time of onset is not known got attention this week from two studies in Stroke.

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, February 11, 2017

Clot-busting drugs for ischemic stroke when the time of onset is not known got attention this week from two studies in Stroke.

Do you really think your stroke department will read and implement this research in the ER? Then you are way too gullible. You are going to have to call the president of the stroke hospital and demand that the stroke department head analyze this to see if changes are needed. Your life may depend on it. Get going and don't be bashful about screaming at the incompetency of the whole stroke hospital.
http://www.medpagetoday.com/Cardiology/Prevention/63066?

by Crystal Phend
Senior Associate Editor, MedPage Today February 10, 2017
This article is a collaboration between MedPage Today® and:

Clot-busting drugs for ischemic stroke when the time of onset is not known got attention this week from two studies in Stroke.
In the Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry, thrombolysis in 502 such cases from 2010 through 2014 was not associated with greater risk of symptomatic intracerebral hemorrhage than seen among the 44,875 treated within a 4.5-hour window (adjusted OR 1.09, 95% CI 0.44-2.67)
Nor was there a significant difference in prospects of functional independence (adjusted OR 0.79, 95% CI 0.56-1.10, for modified Rankin Scale score of 0-2), researchers reported.
The other study was an analysis of baseline data from the first 1,000 patients in the WAKE-UP trial randomizing patients to placebo or thrombolysis based on MRI characteristics, such as mismatch between infarct on diffusion-weighted imaging and fluid-attenuated inversion recovery.
"Almost half of the patients with unknown time of symptom onset stroke otherwise eligible for thrombolysis had MRI findings making them likely to be within a time window for safe and effective thrombolysis," the researchers reported. "Patients with daytime onset unwitnessed stroke differ from wake-up stroke patients with regards to clinical characteristics but are comparable in terms of MRI characteristics of lesion age."