http://www.sciencedirect.com/science/article/pii/S1534580715003937
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The
field of angiogenesis research has primarily focused on the mechanisms
of sprouting angiogenesis. Yet vascular networks formed by vessel
sprouting subsequently undergo extensive vascular remodeling to form a
functional and mature vasculature. This “trimming” includes distinct
processes of vascular pruning, the regression of selected vascular
branches. In some situations complete vascular networks may undergo
physiological regression. Vessel regression is an understudied yet
emerging field of research. This review summarizes the state-of-the-art
of vessel pruning and regression with a focus on the cellular processes
and the molecular regulators of vessel maintenance and regression.
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