You can read this on your own and ask your doctor if this is transferable to humans and to other areas than the olfactory bulb. I'm being good by not commenting on this.
Repeated Paced Mating Increases the Survival of New Neurons in the Accessory Olfactory Bulb
- 1Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Querétaro, Mexico
- 2Escuela Nacional de Estudios Superiores, Unidad Juriquilla Universidad Nacional Autónoma de México (UNAM), Querétaro, Mexico
In female rats, the first sexual experience under paced
mating conditions increases the number of newborn cells that migrate
into the granular layer of the accessory olfactory bulb (AOB). Repeated
paced mating has a potentiating effect on the number of new neurons that
migrate to the AOB compared with a single session 15 days after paced
mating. On the other hand, one paced mating session does no increases
the survival of new cells 45 days after mating. In the present study, we
evaluated if four paced mating sessions could increase the survival of
new neurons in the AOB and main olfactory bulb (MOB) 45 days after
females mated. Sexually naive female rats were ovariectomized,
hormonally supplemented and randomly assigned to one of five groups: (1)
Control, no sexual contact (C); (2) Four sessions in which females were
exposed, without mating, to a sexually experience male rat (SE); (3)
One session of paced mating (PM1); (4) Four sessions of paced mating
(PM4); and (5) Four sessions of non-paced mating (NPM4). In the first
behavioral test, females received the DNA synthesis marker
5-bromo-2′deoxyuridine and were euthanized 45 days later. Our data
showed that the number of new cells that survived in the mitral cell
layer of the AOB decreased when females were exposed to a sexually
active male, in comparison to females that mated once pacing the sexual
interaction. Repeated sexual behavior in pacing conditions did not
increase the survival of new cells in other layers of the MOB and AOB.
However, a significant increase in the percentage of new neurons in the
granular and glomerular layers of the AOB and granular layer of the MOB
was observed in females that mated in four sessions pacing the sexual
interaction. In the group that paced the sexual interaction for one
session, a significant increase in the percentage of neurons was
observed in the glomerular layer of the AOB. Our data suggest that
repeated paced mating increases the percentage of new neurons that
survive in the olfactory bulb of female rats.
Introduction
Mating is a rewarding behavior that induces
physiological and plastic changes. Female rats in natural, semi-natural
and laboratory conditions can pace the sexual interaction, controlling
the frequency and intensity of the sexual stimulation they receive (McClintock and Adler, 1978; Erskine, 1989).
Mating in pacing conditions induces a reward state evaluated by the
conditional place preference (CPP) test in male and female rats, mice
and voles (Agmo and Berenfeld, 1990; Martinez and Paredes, 2001; Kudwa et al., 2005; Coria-Avila et al., 2006, 2008; Parada et al., 2012; Pfaus et al., 2012; Ulloa et al., 2018). When females or males mate without pacing the sexual interaction, this behavior does not induces a reward state (Martinez and Paredes, 2001; Ulloa et al., 2018).
Paced mating also induces plastic changes in the central
nervous system. Adult neurogenesis is one of the most studied plastic
changes. This process has been linked to reproduction from the early
descriptions of its occurrence in adult life. Olfactory bulb (OB)
neurogenesis in adult rodents is divided into three stages:
proliferation, migration and survival. During proliferation (2 days) the
stem cells replicate in the subventricular zone (SVZ) and rostral
migratory stream (RMS). The new cells migrate (15 days) through the RMS
and reach the glomerular (Gl), mitral (Mi), and granular (Gr) layers of
the main and accessory olfactory bulb (MOB and AOB, respectively). The
new cells that survive and integrate (45 days) into the OB layers become
functional (Petreanu and Alvarez-Buylla, 2002; Winner et al., 2002).
These stages are modulated by several internal and external factors.
Thus, half of the new cells will die between 16 and 45 days after birth
if they do not receive appropriate stimulation (Petreanu and Alvarez-Buylla, 2002; Winner et al., 2002).
The modulation of neurogenesis in the olfactory system in
the adult brain in response to social and reproductive stimuli is well
established (Peretto and Paredes, 2014; Bedos et al., 2018; Portillo et al., 2018).
The first sexual experience in paced and non-paced conditions in female
rats increases the proliferation of new cells in the RMS but does not
increase the percentage of immature neurons (Corona et al., 2016).
Paced mating increases the number of new cells that migrate to the Gr
layer of the AOB but does not modify the number of new cells that
survive in the MOB or AOB (Corona et al., 2011, 2016; Alvarado-Martinez and Paredes, 2018).
However, the first paced mating experience increases the percentage of
new cells that survive and differentiate into mature neurons in the Gr
layer of the AOB (Corona et al., 2016).
Constant sexual activity potentiates neurogenesis. Female rats that
mate once a week for 4 weeks, pacing the sexual interaction, show an
increase in the number of new cells and new mature neurons in the Gr
layer of the AOB and MOB (16 days after their first sexual encounter) in
comparison to females that mate four times under non-pacing conditions
and females that mate once under pacing conditions (Arzate et al., 2013).
Thus, repeated paced mating promotes the arrival of more cells that
differentiate into mature neurons in the OB. In the present study, we
evaluated if four sexual behavior tests before the critical time for
cell survival (16 days) increases the number of new cells and neurons
that integrate into the OB in female rats 45 days later.
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