https://www.mdlinx.com/internal-medicine/medical-news-article/2016/05/25/aspirin-diabetes-mellitus-intracranial-hemorrhage-risk/6685421/?
Stroke
Uchiyama S, et al.
The goal of this study was to
assess the impact of aspirin on the risk of stroke and intracranial
hemorrhage in the Japanese Primary Prevention Project (JPPP). Aspirin
did not demonstrate any net benefit for the primary prevention of stroke
in elderly Japanese patients with risk factors for stroke, whereas age
>70 years, smoking, and diabetes mellitus were risk factors for
stroke regardless of aspirin treatment.
Methods
- A total of 14 464 patients (age, 60-85 years) with hypertension, dyslipidemia, and diabetes mellitus participated and were randomized into 2 treatment groups: 100 mg of aspirin or no aspirin.
- The median follow-up period was 5.02 years.
Results
- The cumulative rate of fatal or nonfatal stroke was similar for the aspirin (2.068%; 95% confidence interval [CI], 1.750-2.443) and no aspirin (2.299%; 95% CI, 1.963-2.692) groups at 5 years; the estimated hazard ratio was 0.927 (95% CI, 0.741-1.160; P=0.509).
- Aspirin nonsignificantly reduced the risk of ischemic stroke or transient ischemic attack (hazard ratio, 0.783; 95% CI, 0.606-1.012; P=0.061) and nonsignificantly increased the risk of intracranial hemorrhage (hazard ratio, 1.463; 95% CI; 0.956-2.237; P=0.078).
- A Cox regression adjusted by the risk factors for all stroke, which were age >70 years, smoking, and diabetes mellitus, supported the above result.
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