Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:

Tuesday, August 2, 2016

European research network sets up tool to measure brain blood flow, identifying tell-tale signs of dementia and Alzheimer's very early on

This should be able to be repurposed to identify lack of blood flow post-stroke so an objective diagnosis can tell where the dead and dying areas are. Then use that knowledge to create protocols that address those problem areas. But since we have NO stroke leadership or strategy this will fall thru the cracks like all stroke research. There is never any followup. You will need to hire your own researchers to address this.
A network of over 200 scientists, clinicians and industry partners developed a cost-effective diagnostic tool for measuring the tell-tale signs of dementia and Alzheimer’s. The tool uses a new, non-invasive technique to measure blood flow to the brain, known as Arterial Spin Labelling (ASL). The network set a reference for the best possible way of measuring blood flow, allowing all researchers using ASL in neurodegeneration to compare the network’s results. The three main vendors of MRI machines – GE Healthcare, Siemens Healthcare, and Philips Healthcare – have already taken up the tool.  A company spinning out of the network has raised £1.1 million from the UK’s National Health Service to improve the calibration of ASL devices in order to ensure consistent and reliable results.
Dementia is a major brain disease associated with memory loss, personality changes and confusion. It can rob people of their independence and cause profound distress for individuals and their families.
The condition also represents a significant economic burden. Caring for people affected by dementia accounts for around 1% of global GDP. In Europe, where the number of people aged over 65 is growing, the impact of neurodegenerative diseases could rise.
While the pharmaceutical industry continues to work on therapies that could stem the progression of the illness, imaging experts are developing technologies that can diagnose dementia – even before patients notice classic symptoms such as memory loss .
MRI machines can show anatomical changes in the brain, such as the loss of dying neurones due to Alzheimer’s disease. A technique, known as Arterial Spin Labelling (ASL) , offers something new: a non-invasive way to measure blood flow to the brain.
By magnetising blood in major arteries and following its path to the brain, experts can deduce whether brain cells are being nourished with the oxygen and glucose they need to survive. Low rates of blood flow – known as perfusion – to neuronal cells suggests something may be wrong.
COST Action BM1103 brought together a network of over 200 scientists and clinicians, working alongside industry partners, to develop this cost-effective diagnostic tool that uses the ASL technique. The key was to provide researchers and clinicians with a reliable and comparable way to measure the tell-tale signs of dementia .
“After 15 years of developing ASL around the world, there were a plethora of methodologies and techniques,” says Professor Xavier Golay of University College London. “It was a nightmare for anyone who wanted to work in this field because they did not know where to start or how to achieve the best results .”
Through a COST-funded meeting in Amsterdam in October 2012, members of the COST Action joined forces to find the best possible method to measure perfusion , based on a thorough analysis of the literature. This led to a paper aimed at people working in this area. It was finally published in January 2015 and has become a reference for scientists in the field .
“It has really changed the field, reshaping it in amazing way,” says Professor Golay. “This allows all of us using ASL in neurodegeneration to compare our results and it has even been taken up by the three main vendors of MRI machines – GE Healthcare, Siemens Healthcare, and Philips Healthcare. In terms of impact this is huge.”
As another outcome of the Action, Professor Golay’s spin-out company– Gold Standard Phantoms Limited –has raised £1.1 million from the UK’s National Health Service to improve the calibration of ASL devices in order to ensure consistent and reliable results.
Members of this Action are working with the Quantitative Imaging Biomarkers Alliance (QIBA) to have ASL recognised globally as a biomarker for dementia , and members continue to collaborate through the ASL Network.

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