So these earlier ones were not enough for your doctor to recommend coffee? How do you stand your incompetent doctor that has been incompetent for at least 5 years? And when will your stroke hospital create a 24 hour coffee station? Not doing so should be a fireable offense for the stroke hospital president.
How coffee protects against Parkinson’s Aug. 2014
Coffee May Lower Your Risk of Dementia Feb. 2013
Drinking coffee may reduce your chances of developing Alzheimer's, Parkinson's
Newswise | November 06, 2018
Approximately 500 billion cups of coffee are consumed worldwide each year.
A new study out of the Krembil Brain Institute, part of the Krembil Research Institute, suggests there could be more to that morning jolt of goodness than a boost in energy and attention. Drinking coffee may also protect you against developing both Alzheimer’s and Parkinson’s disease.
"Coffee consumption does seem to have some correlation to a decreased risk of developing Alzheimer’s disease and Parkinson’s disease," says Dr. Donald Weaver, co-director of the Krembil Brain Institute. "But we wanted to investigate why that is—which compounds are involved and how they may impact age-related cognitive decline."
Dr. Weaver enlisted Dr. Ross Mancini, a research fellow in medicinal chemistry, and Yanfei Wang, a biologist, to help. The team chose to investigate three different types of coffee—light roast, dark roast, and decaffeinated dark roast.
"The caffeinated and decaffeinated dark roast both had identical potencies in our initial experimental tests," says Dr. Mancini. "So we observed early on that its protective effect could not be due to caffeine."
Dr. Mancini then identified a group of compounds known as phenylindanes, which emerge as a result of the roasting process for coffee beans. Phenylindanes are unique in that they are the only compound investigated in the study that prevent—or rather, inhibit—both beta amyloid and tau, two protein fragments common in Alzheimer’s and Parkinson’s, from clumping. "So phenylindanes are a dual inhibitor. Very interesting, we were not expecting that," says Dr. Weaver.
As roasting leads to higher quantities of phenylindanes, dark roasted coffee appears to be more protective than light roasted coffee.
"It’s the first time anybody’s investigated how phenylindanes interact with the proteins that are responsible for Alzheimer’s and Parkinson’s," says Dr. Mancini. "The next step would be to investigate how beneficial these compounds are, and whether they have the ability to enter the bloodstream, or cross the blood-brain barrier."
The fact that it’s a natural compound vs synthetic is also a major advantage, says Dr. Weaver.
"Mother Nature is a much better chemist than we are and Mother Nature is able to make these compounds. If you have a complicated compound, it’s nicer to grow it in a crop, harvest the crop, grind the crop out, and extract it than try to make it."
But, he admits, there is much more research needed before it can translate into potential therapeutic options.(So, you won't recommend coffee until it is absolutely proven? What is the downside?)
"What this study does is take the epidemiological evidence and try to refine it and to demonstrate that there are indeed components within coffee that are beneficial to warding off cognitive decline. It’s interesting, but are we suggesting that coffee is a cure? Absolutely not."
—Newswise
A new study out of the Krembil Brain Institute, part of the Krembil Research Institute, suggests there could be more to that morning jolt of goodness than a boost in energy and attention. Drinking coffee may also protect you against developing both Alzheimer’s and Parkinson’s disease.
"Coffee consumption does seem to have some correlation to a decreased risk of developing Alzheimer’s disease and Parkinson’s disease," says Dr. Donald Weaver, co-director of the Krembil Brain Institute. "But we wanted to investigate why that is—which compounds are involved and how they may impact age-related cognitive decline."
Dr. Weaver enlisted Dr. Ross Mancini, a research fellow in medicinal chemistry, and Yanfei Wang, a biologist, to help. The team chose to investigate three different types of coffee—light roast, dark roast, and decaffeinated dark roast.
"The caffeinated and decaffeinated dark roast both had identical potencies in our initial experimental tests," says Dr. Mancini. "So we observed early on that its protective effect could not be due to caffeine."
Dr. Mancini then identified a group of compounds known as phenylindanes, which emerge as a result of the roasting process for coffee beans. Phenylindanes are unique in that they are the only compound investigated in the study that prevent—or rather, inhibit—both beta amyloid and tau, two protein fragments common in Alzheimer’s and Parkinson’s, from clumping. "So phenylindanes are a dual inhibitor. Very interesting, we were not expecting that," says Dr. Weaver.
As roasting leads to higher quantities of phenylindanes, dark roasted coffee appears to be more protective than light roasted coffee.
"It’s the first time anybody’s investigated how phenylindanes interact with the proteins that are responsible for Alzheimer’s and Parkinson’s," says Dr. Mancini. "The next step would be to investigate how beneficial these compounds are, and whether they have the ability to enter the bloodstream, or cross the blood-brain barrier."
The fact that it’s a natural compound vs synthetic is also a major advantage, says Dr. Weaver.
"Mother Nature is a much better chemist than we are and Mother Nature is able to make these compounds. If you have a complicated compound, it’s nicer to grow it in a crop, harvest the crop, grind the crop out, and extract it than try to make it."
But, he admits, there is much more research needed before it can translate into potential therapeutic options.(So, you won't recommend coffee until it is absolutely proven? What is the downside?)
"What this study does is take the epidemiological evidence and try to refine it and to demonstrate that there are indeed components within coffee that are beneficial to warding off cognitive decline. It’s interesting, but are we suggesting that coffee is a cure? Absolutely not."
—Newswise
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