Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, March 9, 2023

Depressive Symptoms Linked to Higher Risk of Acute Stroke

It is your doctor's responsibility to make sure  you don't get depressed. And the way to accomplish that is to have EXACT 100% RECOVERY PROTOCOLS! 

Solve the primary problem of 100% recovery and you don't have to work on the secondary problem of depression.

 

Depressive Symptoms Linked to Higher Risk of Acute Stroke

Patients with depressive symptoms also more likely to have worse recovery outcomes

A photo of a pained-looking woman sitting on a couch with her eyes closed and fist against her mouth.

Symptoms of depression were associated with an increased risk of acute stroke, according to an international case-control study.

Among more than 26,000 participants in the INTERSTROKE study, self-reported depressive symptoms were associated with significantly greater odds of acute stroke (OR 1.46, 95% CI 1.34-1.58), including ischemic stroke (OR 1.44, 95% CI 1.32-1.58) and intracerebral hemorrhage (OR 1.56, 95% CI 1.28-1.91), reported Robert P. Murphy, MB, of the HRB Clinical Research Facility Galway and the School of Medicine at the University of Galway, and co-authors.

While depressive symptoms were not associated with a greater odds of worse baseline stroke severity (OR 1.02, 95% CI 0.94-1.10), they were linked to greater odds of poor functional outcomes 1 month after acute stroke (OR 1.09, 95% CI 1.01-1.19), they noted in Neurologyopens in a new tab or window.

Patients with depressive symptoms were also more likely to die during the first month after stroke (10% vs 8.1%, P=0.003).

"Our results show that symptoms of depression can have an impact on mental health, but also increase the risk of stroke," Murphy told MedPage Today. "Physicians should be looking for these symptoms of depression and can use this information to help guide health initiatives focused on stroke prevention."

"Depression is an important risk factor for acute stroke and is potentially a modifiable contributor to the global burden of stroke," he added. "This study adds to prior evidence, which was predominantly in high-income countries."

INTERSTROKE is a global study that was conducted in 32 countries with a range of economic status, including middle- and low-income countries. This broad approach "adds to the collective body of research that strongly suggests an increased risk of stroke associated with depressive symptoms," Murphy said.

In addition, the use of self-reporting to classify depressive symptoms allowed the researchers to compare people across different countries and regions of the world.

Murphy noted that future studies should look to explore the relationship between depressive symptoms prior to stroke and worse functional outcomes after stroke, which could help determine targeted interventions for patients with depressive symptoms presenting with stroke.

For this study, the researchers included 13,392 patients in 32 countries who were hospitalized with incident acute stroke confirmed by CT or MRI from January 2007 to August 2015. A control group of 13,485 participants were matched based on sex, age, and location.

Of the total 26,877 participants, mean age was 61.7, and 40.4% were women.

Murphy and team asked standardized questions about self-reported depressive symptoms during the previous 12 months and recorded use of prescribed antidepressant medications.

The prevalence of depressive symptoms within the previous 12 months was higher in stroke patients compared with control participants (18.3% vs 14.1%, P<0.001) and differed by region (P for interaction<0.001), with the lowest prevalence in China (6.9% in controls) and the highest in South America (32.2% of controls).

An analysis stratified by number of endorsed questions in the depression questionnaire showed a greater magnitude of association, from mild depressive symptoms (less than three questions endorsed; OR 1.35, 95% CI 1.19-1.53) to moderate depressive symptoms (3-4 questions endorsed; OR 1.58, 95% CI 1.41-1.75) and severe depressive symptoms (five or more endorsed; OR 1.54, 95% CI 1.38-1.72).

The authors acknowledged several limitations to their study, including that depressive symptoms were assessed only at a single baseline examination. In addition, they asked about depressive symptoms occurring over only the last year, which may have underestimated depression ascertainment.

  • author['full_name']

    Michael DePeau-Wilson is a reporter on MedPage Today’s enterprise & investigative team. He covers psychiatry, long covid, and infectious diseases, among other relevant U.S. clinical news. Follow

Disclosures

The INTERSTROKE study was funded by the Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Canadian Stroke Network, Swedish Research Council, Swedish Heart and Lung Foundation, AFA Insurance, and the Health & Medical Care Committee of the Regional Executive Board of Region Västra Götaland, and through unrestricted grants from several pharmaceutical companies, including AstraZeneca, Boehringer Ingelheim, and Pfizer, among others.

The authors reported no relevant disclosures.

Primary Source

Neurology

Source Reference: opens in a new tab or windowMurphy RP, et al "Depressive symptoms and risk of acute stroke: INTERSTROKE case-control study" Neurology 2023; DOI: 10.1212/WNL.0000000000207093.

No comments:

Post a Comment