Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, August 6, 2024

Parietal operculum and motor cortex activities predict motor recovery in moderate to severe stroke

 More useless predicting failure to recover crapola. I'd have everyone fired in this

Parietal operculum and motor cortex activities predict motor recovery in moderate to severe stroke

Article history: Received 9 November 2016 Received in revised form 9 January 2017 Accepted 22 January 2017 Available online 26 January 2017 
Firdaus Fabrice Hannanu a,b , Thomas A. Zefro b,c , Laurent Lamalle a,d,e,f , Olivier Heck g,h , Félix Renard i , Antoine Thuriot i,k , Alexandre Krainik a,d,e,f,g,h , Marc Hommel b,i,j , Olivier Detante b,h,k , Assia Jaillard a,b,i, , on behalf of the ISIS-HERMES Study Group K. Garambois 1 , M. Barbieux-Guillot 2 , I. Favre-Wiki 2 , S. Grand 3 , J.F. Le Bas 4 , A. Moisan 5 , M.J. Richard 6 , F. De Fraipont 6 , J. Gere 7 , S. Marcel 7 , W. Vadot 8 , G. Rodier 8 , D. Perennou 9 , A. Chrispin 9 , P. Davoine 9 , B. Naegele 2 , P. Antoine 2 , I. Tropres 10 , F. Renard 11 1 Stroke Unit Centre Hospitalier UniversitaireGrenoble Alpes [CHUGA], France 2 Stroke Unit CHUGA, France 3 Neuroradiology CHUGA, France 4 Neuroradiologie CHUGA, France 5 Unité Mixte de Thérapie Cellulaire [UMTC] CHUGA, France 6 UMTC, France 7 Stroke Unit, CH Chambéry, France 8 Stroke Unit, CH Annecy, France 9 Rehabilitation Unit CHUGA, France 10 IRMaGe UGA, France 11 AGEIS-UGA, France a Unité IRM 3T-Recherche- UMS IRMaGe Centre Hospitalier Universitaire (CHU) Grenoble Alpes, France b Laboratoire MATICE - Pôle Recherche CHU Grenoble-Alpes, France c Neurometrika, Potomac, MD, United States d IRMaGe - Inserm US-017, France e IRMaGe - CNRS UMS-3552, France f IRMaGe - Université Grenoble-Alpes -, France g Neuroradiologie et IRM-Centre Hospitalier Universitaire Grenoble-Alpes, France h Grenoble Institut des Neurosciences (GIN) Inserm U836-UJF-CEA-CHU, France i AGEIS, EA-UGA 7407 Université Grenoble Alpes, France j Clinatec - CHU Grenoble-Alpes, France k Unité neurovasculaire - CHU Grenoble-Alpes, France
 

 abstract   

 
While motor recovery following mild stroke has been extensively studied with neuroimaging, mechanisms of recovery after moderate to severe strokes of the types that are often the focus for novel restorative therapies remain obscure. We used fMRI to: 1) characterize reorganization occurring after moderate to severe subacute stroke, 2) identify brain regions associated with motor recovery and 3) to test whether brain activity associated with passive movement measured in the subacute period could predict motor outcome six months later. Because many patients with large strokes involving sensorimotor regions cannot engage in voluntary movement, we used passive exion-extension of the paretic wrist to compare 21 patients with subacute ischemic stroke to 24 healthy controls one month after stroke. Clinical motor outcome was assessed with Fugl-Meyer motor scores (motor-FMS) six months later. Multiple regression, with predictors including baseline (one-month) motor-FMS and sensorimotor network regional activity (ROI) measures, was used to determine optimal variable selection for motor outcome prediction. Sensorimotor network ROIs were derived from a meta-analysis of arm voluntary movement tasks. Bootstrapping with 1000 replications was used for internal model validation. During passive movement, both control and patient groups exhibited activity increases in multiple bilateral sensorimotor network regions, including the primary motor (MI), premotor and supplementary motor areas (SMA),

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