Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Wednesday, February 7, 2018

Creation of New Brain Cells May Be Limited

What is your doctor doing to correctly migrate those neurons to the correct places? 
http://neurosciencenews.com/neurogenesis-limits-8444/
Summary: UCSF researchers report neural stem cells only have a very limited capacity to replenish brain tissue.
Source: UCSF.
It used to be that everyone knew that you are born with all the brain cells you’ll ever have. Then UC San Francisco’s Arturo Alvarez-Buylla, PhD, and other neuroscientists discovered in birds and mice that stem cells in certain parts of the brain do produce new neurons throughout the animal’s life.
Ever since, researchers have been eager to find how we might improve our own brain function by boosting its production of new neurons.
Many researchers have long assumed that most stem cells in the body can produce new cells indefinitely, but new research in mice by Alvarez-Buylla’s lab in UCSF’s Eli and Edythe Broad Center of Regeneration Medicine shows that this is not the case in the brain.
Kirsten Obernier, PhD, a postdoctoral researcher in Alvarez-Buylla’s lab, spent six years trying to understand how the brain avoids running out of neural stem cells by catching the cells in the act of dividing. “In the end it was a matter of German determination,” she joked.
By delicately labeling stem cells in the brains of live mice and recording the fates of their offspring, Obernier discovered that the cells don’t divide in a self-renewing fashion, as the field had predicted. Instead, most stem cell divisions produce offspring fated to develop into neurons, reducing the number of stem cells remaining.
The findings surprisingly demonstrate that neural stem cells only have a very limited capacity to replenish brain tissue. This may allow brain regeneration over a mouse’s brief lifespan, Alvarez-Buylla says, but it’s not clear how it could be maintained for the life of longer-lived creatures like ourselves.
“The adult brain seems to carefully choreograph how neural stem cells divide, how many times they divide and whether they do so to replenish them-self or to produce neurons,” Alvarez Buylla added. “Learning these properties about stem cells in the brain is essential for any future attempt to entice these cells to make new neurons for brain repair.”
To get a closer look how these cells divide, Obernier devised a technique for recording movies of their behavior in laboratory dishes without removing them from the surrounding neural tissue that forms their supportive niche.
mouse neurons
Mouse neurons (purple) with their nuclei (blue) and primary cilia (green). NeuroscienceNews.com image is credited to Yi Wang, Vaisse Lab.
The videos confirmed the unorthodox new mode of division Obernier’s labeling experiments had implied, but also revealed the cells’ surprising dynamism: a long tail that touches and probes nearby blood vessels, short arms that poke and prod other stem cells, and a tongue-like antenna that pokes into the nearby ventricular space, as if to “taste” the cerebrospinal fluid there.
“We had seen these cells’ complex shapes before in still images, but the movies revealed that they’re constantly exploring their environment,” Obernier said. “These cells may be actively probing for signals about when more new neurons are needed.”
About this neuroscience research article
Source: Nicholas Weiler – UCSF
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to Yi Wang, Vaisse Lab.
Original Research: Abstract in Cell Stem Cell.
doi:10.1016/j.stem.2018.01.003

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