Deans' stroke musings: Endocannabinoid system and cannabinoids in neurogenesis–new opportunities for neurological treatment? Reports from experimental studies

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, March 8, 2018

Endocannabinoid system and cannabinoids in neurogenesis–new opportunities for neurological treatment? Reports from experimental studies

More followup needed which won't occur because we have NO stroke leadership and we have fucking idiots in the federal legislature that haven't reduced marijuana from a Schedule I drug to complete legalization. 4 pages here and all it says is that we need more research. What a fucking waste of time and effort.
Endocannabinoid system and cannabinoids in neurogenesis–new opportunities for neurological treatment? Reports from experimental studies
Aleksandra Drab1, Mirosław Zagaja1, Agnieszka Haratym-Maj2, Jarogniew Jacek Łuszczki1,3, Marta Andres-Mach1 1 Isobolographic Analysis Laboratory, Institute of Rural Health, Lublin, Poland 2 Department of Physiopathology, Institute of Rural Health, Lublin, Poland 3 Department of Patophysiology, Medical University, Lublin, Poland Drab A, Zagaja M, Haratym-Maj A, Łuszczki JJ, Andres-Mach M. Endocannabinoid system and cannabinoids in neurogenesis – new opportunities for neurological treatment? Reports from experimental studies. J Pre-Clin Clin Res. 2017; 11(1): 76–80. doi: 10.26444/jpccr/74636

Abstract

Neurogenesis is one of the most important phenomenona affecting human life. This process consists of proliferation, migration and differentiation of neuroblasts and synaptic integrations of newborn neurons. Proliferation of new cells continues into old age, also in humans, although the most extensive process of cell formation occurs during the prenatal period. It is possible to distinguish two regions in the brain responsible for neurogenesis: the dentate gyrus (DG) of the hippocampus and the sub-ventricular zone (SVZ). Hippocampal neurogenesis is very sensitive to various physiological and pathological stimuli. The functional integration of the newly-born dentate granule cells into hippocampal circuitry, and their ability to mediate long-term potentiation in DG, has led to the hypothesis that neurogenesis in the adult brain may play a key role in learning and memory function, as well as cognitive dysfunction in some diseases. Brain disorders, such as neurodegenerative diseases or traumatic brain injuries, significantly affect migration, proliferation and differentiation of neural cells. In searching for the best neurological drugs protecting neuronal cells, stimulating neurogenesis, while also developing no side-effects, endocannabinoids proved to be a strong group of substances having many beneficial properties. Therefore, the latest data is reviewed of the various experimental studies concerning the analysis of the most commonly studied cannabinoids and their impact on neurogenesis.