Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, June 14, 2018

Gene therapy reverses rat's paralysis

Cool, but absolutely nothing will be followed up for possible stroke applications since we have NO stroke leadership and NO stroke strategy. You, your children and grandchildren will be screwed after the next stroke. This will take decades to prove out, I'll modify that, your great and great-great grandchildren will be screwed. Thanks to Phil Collis for pointing this out.
https://www.bbc.com/news/health-44484901

Scientists say they have taken a significant step towards the goal of giving paralysed people control of their hands again.
The team at King's College London used gene therapy to repair damage in the spinal cord of rats.
The animals could then pick up and eat sugar cubes with their front paws.
It is early stage research, but experts said it was some of the most compelling evidence that people's hand function could one day be restored.
The spinal cord is a dense tube of nerves carrying instructions from the brain to the rest of the body.
The body repairs a wounded spinal cord with scar tissue.
However, the scar acts like a barrier to new connections forming between nerves.


How the gene therapy works

The researchers were trying to dissolve components of the scar tissue in the rats' spinal cord.
They needed to give cells in the cord a new set of genetic instructions - a gene - for breaking down the scar.
The instructions they gave were for an enzyme called chondroitinase. And they used a virus to deliver them.
Finally, a drug was used to activate the instructions.


The animals regained use of their front paws after the gene therapy had been switched on for two months.
Dr Emily Burnside, one of the researchers, said: "The rats were able to accurately reach and grasp sugar pellets.
"We also found a dramatic increase in activity in the spinal cord of the rats, suggesting that new connections had been made in the networks of nerve cells."
The researchers hope their approach will work for people injured in car crashes or falls.
Prof Elizabeth Bradbury told the BBC: "We find this really exciting, recovery of this type of function, because for spinal injured patients their highest priority is to get their hand function back.
"Being able to pick up a coffee cup, hold a toothbrush, these types of things will have a dramatic increase on their quality of life and their independence."
In 2014, a paralysed man was able to walk with a frame after cells from inside his nose were used to regenerate part of his spinal cord.
The patient, Darek Fidyka, was injured in a knife attack that caused a different type of wound to those in car crashes.
The gene therapy approach is not yet ready for human clinical trials.
Dr Mark Bacon, from the charity Spinal Research, told the BBC: "The data is some of the most compelling I've seen demonstrating restoration of skilled forelimb function.
"It's exciting, but getting approval for gene therapies represents a particular, but not insurmountable, challenge to getting it to the clinic.
"Transferred to the clinic, this research could be life-changing for the millions of people worldwide with paralysis caused by a spinal cord injury."

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