Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Thursday, June 14, 2018

New stroke drug melts brain clots faster, costs less and improves recovery

Do you really think your stroke hospital is innovative enough to read and implement ANY research that might help stroke patients? Up to you, you can demand your hospital create a process to update stroke protocols OR you can hope like hell that it will be there when you need it.  I know I shouldn't be telling the stroke medical world what to do  since I'm not medically trained. You need no medical training to know that current stroke hospital results are a disaster.
https://www.myvmc.com/news/new-stroke-drug-melts-brain-clots-faster-costs-less-improves-recovery/
A breakthrough in stroke medical research found a drug, traditionally used for heart attacks, dissolves blood clots in the brain faster and more effectively than standard stroke drugs.
The EXTEND-IA TNK randomised clinical trial, led by The Royal Melbourne Hospital (RMH) and the University of Melbourne, compared the effectiveness of two drugs, Tenecteplase and Alteplase, in dissolving stroke-causing blood clots in the brain, before patients went on to have clot retrieval surgery.
RMH neurologist, Head of Stroke and study co-principal investigator Bruce Campbell said the study, published in the New England Journal of Medicine, found the drug Tenecteplase was life changing in treatment of ischemic stroke.
“Our study showed that the use of Tenecteplase restored blood flow to the brain before clot retrieval surgery in double the number of patients compared to Alteplase (22 per cent compared with 10 per cent of patients),” Associate Professor Campbell said.
“For one in five patients treated with Tenecteplase, clot retrieval surgery was not required and the earlier restoration of blood flow was associated with improved functional recovery in Tenecteplase-treated patients.
Tenecteplase can be given over 10 seconds compared to the one-hour infusion of Alteplase, which has practical advantages when transferring patients between hospitals for clot retrieval surgery and is also less expensive,” Associate Professor Campbell said.
EXTEND-IA TNK involved 202 participants, across 13 hospitals in Australia and New Zealand, who either received Tenecteplase or Alteplase.
Peter Mitchell, Director Neurointervention Service and study co-principal investigator at the RMH, said the study results were likely to change stroke treatment guidelines and clinical practice.
“In treating stroke, it is critically important to restore blood flow to the brain as soon as possible,” said Professor Mitchell, head of the Statewide Endovascular Clot Retrieval Service at the RMH.
“This is achieved most effectively with clot retrieval surgery, but when the surgery is delayed for patients transferred from hospital to hospital, Tenecteplase is more likely to help restore blood flow than Alteplase.
“Tenecteplase is now likely to become the preferred medication for clot dissolving in stroke patients who need clot retrieval surgery,” Professor Mitchell said.
The EXTEND-IA TNK study was supported by grants from the National Health and Medical Research Council of Australia, the Australasian College of Physicians, The Royal Melbourne Hospital Foundation, the National Heart Foundation of Australia and the Stroke Foundation of Australia. Trial infrastructure was supported by an unrestricted grant from Medtronic who had no role in study design, conduct or analysis.
(Source: University of MelbourneNew England Journal of Medicine)

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