Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, December 9, 2023

Did Fermentation Drive Human Brain Evolution?

I look at this and see that fermenting wine and beer might be helpful even now to keep our brains functioning at a good clip. Don't listen to me, I'm not medically trained.

Did Fermentation Drive Human Brain Evolution?

Summary: Recent research proposes that fermentation, rather than cooking, was the crucial dietary change that enabled the significant growth of the human brain.

The researchers argue that pre-digested, fermented foods provided more accessible nourishment, bridging the gap between the evolution of larger brains and the later advent of cooking.

This theory is bolstered by evidence like the smaller large intestine in humans compared to other primates, indicating adaptation to easier-to-digest foods.

The hypothesis opens new avenues for exploring the impact of fermented foods on human health and the gut microbiome, potentially linking it to both physical and mental well-being.

Key Facts:

  1. Human brains began to enlarge 2.5 million years ago, a million years before the earliest evidence of cooking, suggesting another dietary change spurred this growth.
  2. The study posits that the consumption of fermented foods provided the necessary caloric intake to fuel larger brains in our ancestors.
  3. The human gut’s adaptation to fermented foods and their prevalence in all cultures support this hypothesis.

Source: Harvard

The large, capable human brain is a marvel of evolution, but how it evolved from a smaller primate brain into the creative, complex organ of today is a mystery.

Scientists can pinpoint when our evolutionary ancestors evolved larger brains, which roughly tripled in size as human ancestors evolved from the bipedal primates known as Australopithecines. But why it happened when it did – what spurred that change – has remained elusive.

While some have theorized that the use of fire, and the subsequent invention of cooking, gave our ancestors enough nourishment for our larger-brained ancestors to become dominant, a new theory points to a different spark: fermentation.

This shows skulls.
Hecht suggested that an additional study of brain responses to fermented and non-fermented foods might be useful, as might one of olfactory and taste receptors, perhaps using ancient DNA. Credit: Neuroscience News

The key to understanding how our brains grew is most likely rooted in what – and how – we eat, said Erin Hecht, one of the authors of “Fermentation technology as a driver of human brain expansion,” which has just been published in Nature Communications Biology.

“Brain tissue is metabolically expensive,” said the Human Evolutionary Biology assistant professor. 

“It requires a lot of calories to keep it running, and in most animals, having enough energy just to survive is a constant problem.”

For larger-brained Australopiths to survive, therefore, something must have changed in their diet. Theories put forward have included changes in what these human ancestors consumed or, most popularly, that the discovery of cooking allowed them to garner more usable calories from whatever they ate.

But the problem with this theory is that the earliest evidence places the use of fire at approximately 1.5 million years ago – significantly later than the development of the hominid brain.

“Our ancestors’ cranial capacity began increasing 2.5 million years ago, which conservatively gives us about a 1-million-year gap in the timeline between brain size increasing and the possible emergence of cooking technology,” explained Katherine L. Bryant, one of the paper’s co-authors and currently a researcher at the Institute for Language, Communication, and the Brain at Aix-Marseille Université in France.

“Some other dietary change must have been releasing metabolic constraints on brain size, and fermentation seems like it could fit the bill.”

Added Hecht: “Whatever changed in their diets had to have happened before brains started getting bigger.”

She continued, noting that during the last few years researchers have postulated other options, such as the consumption of rotting meat. In this new paper, Hecht and her team offer a different hypothesis: that cached (or saved) food fermented, and that this “pre-digested” food provided a more accessible form of nourishment, fueling that bigger brain and allowing our larger-brained ancestors to survive and thrive through natural selection.

The shift was probably a happy accident. “This was not necessarily an intentional endeavor,” Hecht posited. “It may have been an accidental side effect of caching food. And maybe, over time, traditions or superstitions could have led to practices that promoted fermentation or made fermentation more stable or more reliable.”

This hypothesis is supported by the fact that the human large intestine is proportionally smaller than that of other primates, suggesting that we adapted to food that was already broken down by the chemical process of fermentation. In addition, fermented foods are found in all cultures and across food groups, from Europe’s wine and cheese to Asia’s soy sauce and natto, or soy beans.

Hecht suggested that an additional study of brain responses to fermented and non-fermented foods might be useful, as might one of olfactory and taste receptors, perhaps using ancient DNA. For the evolutionary biologist, these are all fertile areas for other researchers to pick up on. (Hecht’s focus is more on “how brain circuits have evolved to support complex behaviors” with research on both living humans and dogs.)

As research progresses, Bryant sees possibilities for a wide range of benefits. “This hypothesis also gives us as scientists even more reasons to explore the role of fermented foods on human health and the maintenance of a healthy gut microbiome,” she said. “There have been a number of studies in recent years linking gut microbiome to not only physical but mental health.”

About this evolutionary neuroscience research news

Author: Anne Manning
Source: Harvard
Contact: Anne Manning – Harvard
Image: The image is credited to Neuroscience News

Original Research: Open access.
Fermentation technology as a driver of human brain expansion” by Erin Hecht et al. Communications Biology



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