Send your doctor after this to see if this could possibly relieve CPSP.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=150284&CultureCode=en
New research shows that seven compounds of the countless found in
spider venom block a key step in the body’s ability to pass pain signals
to the brain. The hunt for a medicine based on just one of these
compounds, which would open up a new class of potent painkillers, is now
a step closer according to new research published in the British Journal of Pharmacology.
Pain that cannot be controlled can ruin people’s lives. One in five
people worldwide currently suffer from chronic pain, and existing pain
treatments often fail to provide relief. The economic burden is huge,
with chronic pain in the USA alone estimated to cost around $600 billion
a year, greater than the combined economic cost of cancer, diabetes and
stroke.
People sense that part of their body is hurting when nerves from the
affected area send signals to the brain through what is called the pain
pathway. “A compound that blocks Nav1.7 channels is of particular
interest for us. Previous research shows indifference to pain among
people who lack Nav1.7 channels due to a naturally-occurring genetic
mutation – so blocking these channels has the potential of turning off
pain in people with normal pain pathways,” says research team leader
Professor Glenn King from The University of Queensland’s Institute for
Molecular Bioscience, Australia.
Part of the search for new medicines has focused on the world’s
45,000 species of spiders, many of which kill their prey with venoms
that contain hundreds – or even thousands – of protein molecules. Some
of these molecules block nerve activity. “A conservative estimate
indicates that there are nine million spider-venom peptides, and only
0.01% of this vast pharmacological landscape has been explored so far,”
says researcher Dr Julie Kaae Klint. The challenge was to build a
research method that could search through this huge number of peptides,
looking for the ones that could be useful.
Taking up this challenge, the research team built a system that could
rapidly analyse the compounds in spider venoms. Using their novel
approach, venoms from 206 species of spider were screened, revealing
that 40% of the venoms contained at least one compound that blocked
human Nav1.7 channels. Of the seven promising compounds identified, they
discovered one that was particularly potent, and also had a chemical
structure that suggested it would have high levels of chemical, thermal,
and biological stability, which would be essential for administering a
new medicine. Together these properties make it particularly exciting as
a potential painkiller.
“Untapping this natural source of new medicines brings a distinct
hope of accelerating the development of a new class of painkillers that
can help people who suffer from chronic pain that cannot be treated with
current treatment options,” says Dr Klint. The novel screening approach
used to isolate the protein molecules from spider venoms could also be
applied to other compounds, opening up hope more widely for new and
better medicines.
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