Deans' stroke musings: Permanent whisker removal reduces the density of c-Fos+ cells and the expression of calbindin protein, disrupts hippocampal neurogenesis, and affects spatial-memory-related tasks

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, May 2, 2018

Permanent whisker removal reduces the density of c-Fos+ cells and the expression of calbindin protein, disrupts hippocampal neurogenesis, and affects spatial-memory-related tasks

So ask your doctor explain the contradictory nature of these three pieces of research. How can this be applied to your recovery?

Stroke recovery improved by sensory deprivation, mouse study shows Feb. 2018

Trimming animals’ whiskers activates brain to rewire damaged circuits after stroke

Tickling rat whiskers to improve their stroke rehabilitation? May 2013

Permanent whisker removal reduces the density of c-Fos+ cells and the expression of calbindin protein, disrupts hippocampal neurogenesis, and affects spatial-memory-related tasks

Oscar Gonzalez-Perez^1*,

Veronica Lopez-Virgen¹ and Nereida Ibarra-Castaneda¹

¹School of Psychology, University of Colima, Mexico

Facial vibrissae, commonly known as whiskers, are the main sensitive tactile system in rodents. Whisker stimulation triggers neuronal activity that promotes neural plasticity in the barrel cortex and helps create spatial maps in the adult hippocampus. Moreover, activity-dependent inputs and calcium homeostasis modulate adult neurogenesis. Therefore, the neuronal activity of the barrel cortex possibly regulates hippocampal functions and neurogenesis. To assess whether tactile information from facial whiskers may modulate hippocampal functions and neurogenesis, we permanently eliminated whiskers in CD1 male mice and analyzed the effects in cellular composition, molecular expression and memory processing in the adult hippocampus. Our data indicated that the permanent deprivation of whiskers reduced in 4-fold the density of c-Fos+ cells (a calcium-dependent immediate early gene) in cornu ammonis subfields (CA1, CA2 and CA3) and 4.5-fold the dentate gyrus. A significant reduction in the expression of calcium-binding proteincalbindin-D28k was also observed in granule cells of the dentate gyrus. Notably, these changes coincided with an increase in apoptosis and a decrease in the proliferation of neural precursor cells in the dentate gyrus, which ultimately reduced the number of BrdU+NeuN+ mature neurons generated after whisker elimination. These abnormalities in the hippocampus were associated with a significant impairment of spatial memory and navigation skills. This is the first evidence indicating that tactile inputs from vibrissal follicles strongly modify the expression of c-Fos and calbindin in the dentate gyrus, disrupt different aspects of hippocampal neurogenesis, and support the notion that spatial memory and navigation skills strongly require tactile information in the hippocampus.