Deans' stroke musings: Vitamin D and Rehabilitation after Stroke: Status of Art

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, March 21, 2020

Vitamin D and Rehabilitation after Stroke: Status of Art

So ask your doctor if you have a vitamin D deficiency and the solution for that.

Vitamin D and Rehabilitation after Stroke: Status of Art

Mariacristina Siotto, Massimo Santoro * and Irene Aprile IRCCS, Fondazione Don Carlo Gnocchi, 20121 Milan, Italy; msiotto@dongnocchi.it (M.S.); iaprile@dongnocchi.it (I.A.) * Correspondence: masantoro@dongnocchi.it; Tel.: +39-063-308-6318
Received: 30 January 2020; Accepted: 10 March 2020; Published: 13 March 2020

Abstract:

Stroke is the ﬁrst cause of disability in the population and post-stroke patients admitted to rehabilitation units often present a malnutrition status which can inﬂuence nutritional indices and then vitamin levels. Vitamin D deﬁciency seems implicated beyond stroke severity and stroke risk, and also aﬀects post stroke recovery. Some studies on vitamin D levels and outcome in stroke patients are available but very few data on vitamin D levels and outcome after rehabilitation treatment are reported. This literature review shows the possible relationship between vitamin D deﬁciency and recovery in post-stroke patients undergoing rehabilitation treatment. Moreover, because several studies have reported that single nucleotide polymorphisms and promoter methylation in genes are involved in vitamin D metabolism and might aﬀect circulating vitamin D levels, these aspects are evaluated in the current paper. From the studies evaluated in this review, it emerges that vitamin D deﬁciency could not only have an important role in the recovery of patients undergoing rehabilitation after a stroke, but that genetic and epigenetic factors related to vitamin D levels could have a crucial role on the rehabilitation outcome of patients after stroke. Therefore, further studies are necessary on stroke patients undergoing rehabilitation treatment, including: (a) the measurement of the 25(OH) vitamin D serum concentrations at admission and post rehabilitation treatment; (b) the identiﬁcation of the presence/absence of CYP2R1, CYP27B1, CYP24A1 and VDR polymorphisms, and (c) analysis of the methylation levels of these genes pre- and post-rehabilitation treatment.