Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, June 8, 2016

Statins and Risk of Rheumatoid Arthritis - A Nested Case-Control Study

But high-intensity statins should not be used anymore.

FDA announces new safety recommendations for high-dose simvastatin 


http://onlinelibrary.wiley.com/doi/10.1002/art.39774/abstract;jsessionid=F552C59330C812204052C6CFA1304DDC.f03t02
  1. Koray Tascilar MD1,2,
  2. Sophie Dell'Aniello MSc1,
  3. Marie Hudson MD, MPH, FRCPC1,3,4 and
  4. Samy Suissa PhD1,5,*
DOI: 10.1002/art.39774

SEARCH

Get PDF (792K)

Keywords:

  • Rheumatoid arthritis;
  • statins;
  • prevention

Abstract

Objective: Statins have anti-inflammatory/immunomodulatory effects that may be useful to prevent rheumatoid arthritis (RA) but previous observational studies about the risk of RA with statin use provided conflicting results. The aim of this study was to determine whether high-intensity statin treatment is associated with a lower risk of rheumatoid arthritis.
Methods: Using data from the UK Clinical Practice Research Datalink, we performed a nested case-control analysis in a population-based cohort of new statin users between 1997 and 2009, followed until a first diagnosis of RA, death, end of registration or end of 2009. For each case of RA, 10 age, sex and calendar year-matched controls were randomly selected from risk sets. We estimated the hazard ratio (HR) of incident RA in the highest quintile of duration-weighted average statin intensity compared with the lowest, using conditional logistic regression. Models were adjusted for smoking status, total cholesterol levels, obesity, history of cardiovascular disease, coexistent autoimmune diseases, hypothyroidism and persistence with treatment.
Results: The cohort included 528,654 new users of statins, with 1,357 new RA cases during a mean 3.3 years of follow-up, for an incidence rate of 7.9 per 10,000 person-years. Cases were more likely to be smokers, have other autoimmune diseases and lower total cholesterol levels at baseline. The incidence of RA was lower in the highest statin intensity quintile (adjusted HR 0.77; 95% CI: 0.63-0.95) in comparison to the lowest quintile.
Conclusions: In this large population-based study, high-intensity statin treatment was associated with a reduced risk of RA in comparison with low-intensity statins. This article is protected by copyright. All rights reserved.
Get PDF (792K)
Posted by at
Labels: , ,

No comments:

Post a Comment

Subscribe to: Post Comments (Atom)