http://link.springer.com/chapter/10.1007/978-3-319-49343-5_6
- Alline C. Campos
- , Juan Paraíso-Luna
- , Manoela V. Fogaça
- , Francisco S. Guimarães
- , Ismael Galve-Roperh
Abstract
Neurogenesis plays an
indispensable role in the formation of the nervous system during
development. The discovery that the adult brain still maintains
neurogenic niches that allow the continued production of new cells after
birth has changed the field of neuroscience. It has also opened a new
venue of opportunities for the treatment of central nervous system
disorders related to neuronal loss. This chapter has reviewed the
studies showing that genetic or pharmacological manipulation of
cannabinoid receptors (CB1 and CB2) or the enzymes
responsible for endocannabinoid metabolism modify/regulate cell
proliferation and neurogenesis during development and in the adult brain.
A better characterization of the mechanisms involved in these effects
could contribute to the development of new therapeutic alternatives to
neurodegenerative and psychiatric disorders.
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