Deans' stroke musings: Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: A prospective analysis of up to 347,077 individuals and 8,368 cases

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, March 14, 2019

Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: A prospective analysis of up to 347,077 individuals and 8,368 cases

Bad research since it doesn't take into account the protective effects of coffee on Parkinsons and dementia. Not complete enough research.

How coffee protects against Parkinson’s Aug. 2014

Coffee May Lower Your Risk of Dementia Feb. 2013

Long-term coffee consumption, caffeine metabolism genetics, and risk of cardiovascular disease: A prospective analysis of up to 347,077 individuals and 8,368 cases

American Journal of Clinical Nutrition — Zhou A, et al. | March 12, 2019

Researchers used data from the UK Biobank, as well as logistic regression, to examine whether the link between habitual coffee consumption and cardiovascular disease (CVD) risk varied with CYP1A2 (a functional variant at cytochrome P450 1A2) genotype or a genetic score for caffeine metabolism (caffeine-GS). They analyzed data for 347,077 individuals, with 8,368 incident CVD cases. An elevated CVD risk was reported for nondrinkers, drinkers of decaffeinated coffee, and those who reported drinking >6 cups/day vs those drinking 1–2 cups/day (increase in odds by 11%, 7%, and 22%, respectively). A modest increase in CVD risk was observed in association with heavy coffee consumption, but genetic variants affecting caffeine metabolism had no impact on this link.

Read the full article on American Journal of Clinical Nutrition