http://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2815%2900339-7/abstract
Traumatic brain injury (TBI) research is in the midst of a golden age in both preclinical and clinical arenas, emphasised by large comparative effectiveness trials targeting the need for stronger evidence-based care. These trials include the Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) trial in adults and the Approaches and Decisions for Acute Pediatric TBI (ADAPT) trial in children,1,2 along with the development of clinical and preclinical common data elements.3,4 Other factors fueling this golden age are funding from the US Department of Defense for research on blast-induced TBI and its links to post-traumatic stress disorder, and the media storm that has accompanied both the identification of chronic traumatic encephalopathy (CTE) resulting from mild repetitive TBI in elite athletes and the possibility that TBI is linked to the development of many neurodegenerative diseases.
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