http://www.freepatentsonline.com/y2015/0335739.html
Title:
METHODS FOR TREATING INFLAMMATION
Document Type and Number:
Kind Code:
A1
Abstract:
The invention provides methods and compositions for
inhibiting, reducing or slowing inflammation or inflammatory diseases,
for reducing sequestration or collecting or localization of macrophages,
for treating a disease caused all or in part by or characterized by
inflammation such as, for instance, chronic inflammation, for
inhibiting, slowing, reversing or preventing atherosclerosis, and for
increasing insulin sensitivity, decreasing or inhibiting resistance to
insulin, or treating diabetes by inhibiting, inhibiting the biological
activity of or antagonizing an axonal guidance protein. The methods may
feature administering to a subject a therapeutically effective amount of
an agent effective to inhibit or reduce the biological activity of an
axonal guidance protein or a receptor of the axonal guidance protein, or
an analog, derivative or combination thereof. The disease may be, for
instance, one of atherosclerosis, rheumatoid arthritis, tuberculosis,
autoimmune syndromes and obesity where macrophage accumulation in
adipose tissue is known to promote insulin resistance.
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