Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Wednesday, January 18, 2017

Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials

Where is your doctors' coffee protocol? I've only written 116 posts on coffee, most of them on the benefits. Does your doctor not read any research or employ an analyst to summarize research for them? Such incompetency should require a call to the president and board of directors to see how far up the rot goes. Sometimes you need to amputate before the rot kills the patient.
https://www.mdlinx.com/family-medicine/medical-news-article/2016/12/13/coffee-chlorogenic-acid-vascular-phenolics-flow-mediated-dilatation-fmd-/6965864/?
Clinical Nutrition, 12/13/2016
Mills CE, et al. – The researchers performed this work to inspect the effect of coffee intake rich in chlorogenic acid on human vascular function and whether chlorogenic acids (CGAs) are involved in potential effects. The results of this study reveal that coffee intake acutely enhances human vascular function, an effect, in part, mediated by 5–CQA and its physiological metabolites.

Methods

  • For the purpose of this study, two acute randomized, controlled, cross-over human intervention trials were conducted.
  • The effect of coffee intake, matched for caffeine but differing in CGA content (89, and 310 mg) on flow-mediated dilation (FMD) was evaluated in 15 healthy male subjects.
  • In a second intervention trial conducted with 24 healthy male subjects, the effect of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee (5-CQA; 450 mg and 900 mg) on FMD was also examined.   

Results

  • Researchers observed a bi-phasic FMD response after low and high polyphenol, (89 mg and 310 mg CGA) intake, with increments at 1 (1.10 ± 0.43% and 1.34 ± 0.62%, respectively) and 5 (0.79% ± 0.32 and 1.52% ± 0.40, respectively) hours post coffee consumption.  
  • The results of this study showed that FMD responses to coffee intake was closely paralleled by the appearance of CGA metabolites in plasma, notably 3-, 4- and 5-CQA and ferulic-4'-O-sulfate at 1 h and isoferulic-4'-O-glucuronide and ferulic-4'-O-sulfate at 5 h.
  • The findings demonstrated that intervention with purified 5-CQA (450 mg) also led to an improvement in FMD response relative to control (0.75 ± 1.31% at 1 h post intervention, p = 0.06) and concomitant appearance of plasma metabolites.   
Go to PubMed Go to Abstract Print Article Summary Cat 2 CME Report

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