Deans' stroke musings: Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, May 1, 2017

Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans

I'm sure something in here could be useful for stroke rehab.
http://www.cell.com/current-biology/fulltext/S0960-9822%2817%2930326-3

Daniel S. Rizzuto¹⁵

Michael J. Kahana¹⁵^,¹⁶^,

Correspondence information about the author Michael J. Kahana

Email the author Michael J. Kahana

¹⁵These authors contributed equally

¹⁶Lead Contact

Publication stage: In Press Corrected Proof

DOI: http://dx.doi.org/10.1016/j.cub.2017.03.028

Article Info

Highlights

•Intracranial brain stimulation has variable effects on episodic memory performance
•Stimulation increased memory performance when delivered in poor encoding states
•Recall-related brain activity increased after stimulation of poor encoding states
•Neural activity linked to contextual memory predicted encoding state modulation

Summary

People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Using recordings from neurosurgical epilepsy patients with intracranially implanted electrodes, we trained multivariate classifiers to discriminate spectral activity during learning that predicted remembering from forgetting, then decoded neural activity in later sessions in which we applied stimulation during learning. Stimulation increased encoding-state estimates and recall if delivered when the classifier indicated low encoding efficiency but had the reverse effect if stimulation was delivered when the classifier indicated high encoding efficiency. Higher encoding-state estimates from stimulation were associated with greater evidence of neural activity linked to contextual memory encoding. In identifying the conditions under which stimulation modulates memory, the data suggest strategies for therapeutically treating memory dysfunction.