Deans' stroke musings: Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, May 2, 2017

Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs

Who gives a fuck about discussing and reviewing possible drugs you lazy fucking idiots. We need protocols and translational efforts that actually get survivors to 100% recovery. Don't just sit on your fucking ass and discuss, trillions of neurons are dying every second.
I guess you are on your own to get the research and hire researchers to solve the problem. No one else is going to do it. I guess everyone in stroke takes their cues from our fucking failures of stroke associations doing 'All talk and no action' or 'All hat and no cattle'.

https://www.ncbi.nlm.nih.gov/pubmed/28447573

Wu KJ¹, Yu S¹, Lee JY², Hoffer B³, Wang Y¹.

Author information

Abstract

Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone(SVZ) of adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes which occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs, and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke.