Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Saturday, May 6, 2017

Resveratrol may reduce arterial stiffness in patients with diabetes

You will have to ask your doctor to translate this into amounts of wine needed daily.  But followup needed, I would volunteer since actual foods are always better that pill forms.
http://www.healio.com/cardiology/vascular-medicine/news/online/%7B3a46e8d5-90ea-4e06-8071-b69a007b6497%7D/resveratrol-may-reduce-arterial-stiffness-in-patients-with-diabetes?utm_source=selligent&utm_medium=email&utm_campaign=cardiology%20news&m_bt=592835816269
Resveratrol reversed arterial stiffness in patients with type 2 diabetes, according to an abstract presented at the American Heart Association’s Arteriosclerosis, Thrombosis and Vascular Biology/Peripheral Vascular Disease Scientific Sessions.
“This adds to emerging evidence that there may be interventions that may reverse the blood vessel abnormalities that occur with aging and are more pronounced in people with type 2 diabetes and obesity,” Naomi M. Hamburg, MD, MS, FACC, associate professor of medicine and chief of the vascular biology section at the Boston University School of Medicine, said in a press release.
Hamburg and colleagues measured aortic stiffness in 57 patients (mean age, 56 years; 52% women; mean BMI, 31.7 kg/m2) with type 2 diabetes. Patients were assigned 100 mg per day of resveratrol for 2 weeks, then 300 mg per day for 2 weeks or placebo.
Naomi M. Hamburg, MD, MS, FACC
Naomi M. Hamburg
Carotid-femoral pulse wave velocity was numerically lower in the resveratrol group (P = .18) compared with those assigned placebo. Patients with high arterial stiffness at the start of the study (n = 23) experienced reduced carotid-femoral pulse wave velocity without altering systemic BP when taking resveratrol 300 mg (9.1%) and resveratrol 100 mg (4.8%), whereas stiffness in the placebo group increased.
Researchers collected venous endothelial cells from seven patients assigned resveratrol and discovered increased SIRT1 activity, which may underlie the arterial stiffening reversal in the resveratrol group.
Hamburg and colleagues did not observe any effect of resveratrol on brachial artery flow-mediated dilation, reactive hyperemia or pulse amplitude tonometry.
“We found that resveratrol also activates the longevity gene SIRT1 in humans, and this may be a potential mechanism for the supplements to reduce aortic stiffness,” Ji-Yao Ella Zhang, PhD, postdoctoral fellow at Boston University Whitaker Cardiovascular Institute, said in the release. “However, the changes in this small and short-term study are not proof. Studies with longer treatment are needed to test the effects of a daily resveratrol supplement on vascular function.” – by Darlene Dobkowski
Reference:
Zhang J, et al. Poster 164. Presented at: American Heart Association’s Arteriosclerosis, Thrombosis and Vascular Biology | Peripheral Vascular Disease Scientific Sessions; May 4-6, 2017; Minneapolis.

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